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EJNMMI Research

Table 2 ROC area under the curve (AUC) data together with sensitivity and specificity performance for Southampton-specific striatal binding ratios (SBR) and BRASS striatal and putaminal SBR

From: The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

 

Calibrated

Non-calibrated

ACSC

IRNC

FBP

ACSC

IRNC

FBP

ROC (AUC)

BRASS striatum

0.901

0.916

0.884

0.904

0.915

0.897

BRASS putamen

0.915

0.924

0.897

0.919

0.921

0.906

Southampton

0.876

0.866

0.876

0.874

0.866

0.874

Sensitivity

BRASS striatum

83.7

86.1

83.7

79.1

67.4

74.4

BRASS putamen

83.7

83.7

81.4

83.7

76.7

81.4

Southampton

90.7

76.7

67.4

65.1

67.4

60.5

Specificity

BRASS striatum

85.3

82.4

79.4

85.3

91.2

88.2

BRASS putamen

82.4

85.3

79.4

85.3

91.2

88.2

Southampton

82.4

82.4

82.4

88.2

88.2

88.2

  1. The table shows the results for data with and without using a phantom calibration for iterative reconstruction with attenuation and scatter/septal penetration reconstruction (ACSC), iterative reconstruction with no corrections (IRNC) and filtered back projection reconstruction, again with no corrections (FBP). The best performance measure for each quantification technique is in bold, while the weakest is shown in italics
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