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Table 2 ROC area under the curve (AUC) data together with sensitivity and specificity performance for Southampton-specific striatal binding ratios (SBR) and BRASS striatal and putaminal SBR

From: The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

  Calibrated Non-calibrated
ACSC IRNC FBP ACSC IRNC FBP
ROC (AUC) BRASS striatum 0.901 0.916 0.884 0.904 0.915 0.897
BRASS putamen 0.915 0.924 0.897 0.919 0.921 0.906
Southampton 0.876 0.866 0.876 0.874 0.866 0.874
Sensitivity BRASS striatum 83.7 86.1 83.7 79.1 67.4 74.4
BRASS putamen 83.7 83.7 81.4 83.7 76.7 81.4
Southampton 90.7 76.7 67.4 65.1 67.4 60.5
Specificity BRASS striatum 85.3 82.4 79.4 85.3 91.2 88.2
BRASS putamen 82.4 85.3 79.4 85.3 91.2 88.2
Southampton 82.4 82.4 82.4 88.2 88.2 88.2
  1. The table shows the results for data with and without using a phantom calibration for iterative reconstruction with attenuation and scatter/septal penetration reconstruction (ACSC), iterative reconstruction with no corrections (IRNC) and filtered back projection reconstruction, again with no corrections (FBP). The best performance measure for each quantification technique is in bold, while the weakest is shown in italics