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EJNMMI Research
Fig. 2 | EJNMMI Research

Fig. 2

From: Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

Fig. 2

MRI of a GOT1 xenograft. a MRI of a representative GOT1 tumor (animal no. 3 in the 5 + 10 MBq group imaged on day -1, prior to priming administration) after delineation for volume calculation. The fluctuating intra-tumor intensity illustrates the heterogeneity of tumor tissue, containing both viable (hyper-intense) and necrotic (hypo-intense) regions. The coil sensitivity profile makes tissues closer to the coil (bottom of image) brighter than more distant tissues, which confounds histogram analysis. This is corrected for in b where histogram equalization (correcting for coil sensitivity profile) and 3 × 3 median noise filtering has been applied

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