Table 1 TBC of 11C-metformin in RenTGF-β1 mice (Tg), OCT1/2 KO mice, or wildtype mice treated with an OCT1/2 inhibitor (cimetidine) or MATE1 inhibitor (pyrimethamine), respectively, relative to the appropriate control mice
From: Renal PET-imaging with 11C-metformin in a transgenic mouse model for chronic kidney disease
Group | Fold-change in TBC | P value |
|---|---|---|
Control | 1 | N.A. |
Tg (n = 8) | 1.8 ↓ | 0.011 |
OCT1/2 KO (n = 4) | 3.0 ↓ | <0.001 |
Cimetidine (n = 5) | 2.5 ↓ | 0.011 |
Pyrimethamine (n = 4) | 1.1 ↑ | 0.357 |