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Table 1 TBC of 11C-metformin in RenTGF-β1 mice (Tg), OCT1/2 KO mice, or wildtype mice treated with an OCT1/2 inhibitor (cimetidine) or MATE1 inhibitor (pyrimethamine), respectively, relative to the appropriate control mice

From: Renal PET-imaging with 11C-metformin in a transgenic mouse model for chronic kidney disease

Group Fold-change in TBC P value
Control 1 N.A.
Tg (n = 8) 1.8 ↓ 0.011
OCT1/2 KO (n = 4) 3.0 ↓ <0.001
Cimetidine (n = 5) 2.5 ↓ 0.011
Pyrimethamine (n = 4) 1.1 ↑ 0.357
  1. N.A. not available