The effect of dimethyl sulfoxide on the induction of DNA strand breaks in plasmid DNA and colony formation of PC Cl3 mammalian cells by alpha-, beta-, and Auger electron emitters 223Ra, 188Re, and 99mTc

EJNMMI Research

Table 1 Regression parameters and protection factors obtained by analyzing the survival curves for ²²³Ra, ¹⁸⁸Re, or ^99mTc in the presence or absence of 0.2 M DMSO

Radionuclide	Experimental condition	Regression parameters (mean ± standard error)		Protection factors
Radionuclide	Experimental condition	a	b	Protection factors
²²³Ra	Without DMSO	0.616 ± 0.012 (kBq/ml)⁻¹		1.23 ± 0.04
²²³Ra	With DMSO	0.501 ± 0.008 (kBq/ml)⁻¹		1.23 ± 0.04
¹⁸⁸Re	Without DMSO	0.612 ± 0.038 (MBq/ml)⁻¹	0.071 ± 0.100 (MBq/ml)⁻²	1.20 ± 0.19
¹⁸⁸Re	With DMSO	0.512 ± 0.049 (MBq/ml)⁻¹	0.050 ± 0.012 MBq/ml)⁻²	1.20 ± 0.19
^99mTc	Without DMSO	0.172 ± 0.003 (MBq/ml)⁻¹		1.34 ± 0.05
^99mTc	With DMSO	0.128 ± 0.002 (MBq/ml)⁻¹		1.34 ± 0.05