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Table 1 IC50 values of different metal-chelate conjugates consisting of cyclo(-d-Tyr-N-Me-d-Orn(spacer-[M 3+ ]chelator)-l-Arg-l-2-Nal-Gly-), expressed as mean ± SD (n = 3)

From: The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity

Compound IC50/nM Compound IC50/nM
1 (DOTA) 102 ± 17 2 (DOTAGA) 654 ± 263
 [natGa3+]1 24.8 ± 2.5  [natGa3+]2 380 ± 102
 [natBi3+]1 22.1 ± 7.0  [natBi3+]2 29.4 ± 7.6
 [natCu2+]1 131 ± 11  [natCu2+]2 1165 ± 220
 [natLu3+]1 40.9 ± 12  [natLu3+]2 188 ± 2.8
 [natY3+]1 40.8 ± 27  [natY3+]2 126 ± 89
3 (NOTA) 253 ± 49 4 (NODAGA) 275 ± 106
 [natGa3+]3 17.8 ± 7.7  [natGa3+]4 342 ± 72
 [natCu2+]3 46.1 ± 26  [natCu2+]4 343 ± 10
 [natF]AlF-3 220 ± 57   
5 (SCN-Bn-NODA) 115 ± 24 6 (DTPA) 53 ± 7.9
 [natF]AlF-5 329 ± 49  [natY3+]6 156 ± 6.7
7 (SCN-Bn-DTPA) 200 ± 73  [natLu3+]6 111 ± 77
 [natIn3+]7 74.1 ± 2.4  [natIn3+]6 90 ± 42
8 (SCN-Bn-DFO) 105 ± 35  [natCu2+]6 175 ± 66
 [natZr4+]8 148 ± 27   
  1. FC131 as control 9.9 ± 2.4 nM