Fig. 2

Representative images of the macroscopic appearance of the aorta of a cholesterol-fed ApoE^−/− mouse (a) and a normally fed C57BL/6 control mouse (b). Note the presence of atherosclerotic plaques predominantly located at the level of the aortic arch and the supra-aortic vessels of the hyperlipidemic mouse (white arrows); no plaque is apparent in the aorta of the control mouse