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Table 5 Blood urea nitrogen and creatinine levels in blood plasma of mice injected with 161Tb-folate or 177Lu-folate

From: Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of 161Tb-folate and 177Lu-folate

  Control 161Tb-folate 177Lu-folate
Week Group A Group B: 10 MBq Group C: 20 MBq Group D: 30 MBq Group E: 10 MBq Group F: 20 MBq Group G: 30 MBq
Blood urea nitrogen (mM)
8 8.8 ± 0.8 (n = 7) 9.0 ± 1.3 (n = 5) 8.6 ± 0.6 (n = 6) 14 ± 7.5* (n = 6) 11 ± 0.8 (n = 6) 8.3 ± 0.6 (n = 6) 8.8 ± 0.6 (n = 4)
19 9.8 ± 0.6 (n = 9) 9.4 ± 0.6 (n = 6) 11 ± 1.6 (n = 5) 23 (n = 1) 10 ± 0.7 (n = 6) 9.3 ± 2.5 (n = 6) 26 ± 13*** (n = 6)
26 8.5 ± 0.8 (n = 9) 8.6 ± 1.6 (n = 6) 16 ± 12 (n = 5) n.d. 9.2 ± 0.5 (n = 5) 21 ± 7.2 (n = 5) >50*** (n = 1)
Terminal 8.4 ± 1.4 (n = 9) 9.2 ± 3.0 (n = 6) >50 (n = 1) >50 (n = 2) 10 ± 2.6 (n = 5) 38 ± 4.1*** (n = 4) >50*** (n = 5)
13 ± 3.2 (n = 5) 42 ± 8.1*** (n = 4)
Creatinine (μM)
8 <18 (n = 3) <18 (n = 3) <18 (n = 6) <18 (n = 1) <18 (n = 3) <18 (n = 3) <18 (n = 4)
21 ± 3.5 (n = 4) 32 ± 1.4 (n = 2) 31 ± 14 (n = 5) 20 ± 1.0 (n = 3) 18 (n = 1)
19 26 ± 9.6 (n = 8) <18 (n = 2) <18 (n = 3) 32 (n = 1) <18 (n = 3) <18 (n = 2) 25 ± 6.3 (n = 6)
25 ± 7.3 (n = 4) 21 ± 4.9 (n = 2) 22 ± 0.6 (n = 3) 18 ± 0 (n = 3)
26 <18 (n = 4) <18 (n = 4) <18 (n = 2) n.d. 30 ± 19 (n = 5) 33 ± 7.6 (n = 5) 46 (n = 1)
  20 ± 1.7 (n = 4) 22 ± 0.7 (n = 2) 33 ± 5.9 (n = 3)
Terminal <18 (n = 3) 21 ± 3.8 (n = 6) <18 (n = 1) 77 ± 17* (n = 6) 25 ± 7.6 (n = 5) <18 (n = 2) 107 ± 35** (n = 5)
24 ± 5.1 (n = 6) 51 ± 48 (n = 5) 63 ± 46 (n = 2)
  1. The blood plasma parameters were determined in Week 8, 19, 26 and before euthanasia (terminal)
  2. Abbreviations: n.d. not determined (already euthanized), n number of mice
  3. Statistics: comparison of treated animals to control; *P < 0.05, **P < 0.01, ***P < 0.001
  4. Detection limits: blood urea nitrogen: 50 mM; creatinine: 18 μM