Control | 161Tb-folate | 177Lu-folate | |||||
---|---|---|---|---|---|---|---|
Week | Group A | Group B: 10 MBq | Group C: 20 MBq | Group D: 30 MBq | Group E: 10 MBq | Group F: 20 MBq | Group G: 30 MBq |
Blood urea nitrogen (mM) | |||||||
8 | 8.8 ± 0.8 (n = 7) | 9.0 ± 1.3 (n = 5) | 8.6 ± 0.6 (n = 6) | 14 ± 7.5* (n = 6) | 11 ± 0.8 (n = 6) | 8.3 ± 0.6 (n = 6) | 8.8 ± 0.6 (n = 4) |
19 | 9.8 ± 0.6 (n = 9) | 9.4 ± 0.6 (n = 6) | 11 ± 1.6 (n = 5) | 23 (n = 1) | 10 ± 0.7 (n = 6) | 9.3 ± 2.5 (n = 6) | 26 ± 13*** (n = 6) |
26 | 8.5 ± 0.8 (n = 9) | 8.6 ± 1.6 (n = 6) | 16 ± 12 (n = 5) | n.d. | 9.2 ± 0.5 (n = 5) | 21 ± 7.2 (n = 5) | >50*** (n = 1) |
Terminal | 8.4 ± 1.4 (n = 9) | 9.2 ± 3.0 (n = 6) | >50 (n = 1) | >50 (n = 2) | 10 ± 2.6 (n = 5) | 38 ± 4.1*** (n = 4) | >50*** (n = 5) |
13 ± 3.2 (n = 5) | 42 ± 8.1*** (n = 4) | ||||||
Creatinine (μM) | |||||||
8 | <18 (n = 3) | <18 (n = 3) | <18 (n = 6) | <18 (n = 1) | <18 (n = 3) | <18 (n = 3) | <18 (n = 4) |
21 ± 3.5 (n = 4) | 32 ± 1.4 (n = 2) | 31 ± 14 (n = 5) | 20 ± 1.0 (n = 3) | 18 (n = 1) | |||
19 | 26 ± 9.6 (n = 8) | <18 (n = 2) | <18 (n = 3) | 32 (n = 1) | <18 (n = 3) | <18 (n = 2) | 25 ± 6.3 (n = 6) |
25 ± 7.3 (n = 4) | 21 ± 4.9 (n = 2) | 22 ± 0.6 (n = 3) | 18 ± 0 (n = 3) | ||||
26 | <18 (n = 4) | <18 (n = 4) | <18 (n = 2) | n.d. | 30 ± 19 (n = 5) | 33 ± 7.6 (n = 5) | 46 (n = 1) |
20 ± 1.7 (n = 4) | 22 ± 0.7 (n = 2) | 33 ± 5.9 (n = 3) | |||||
Terminal | <18 (n = 3) | 21 ± 3.8 (n = 6) | <18 (n = 1) | 77 ± 17* (n = 6) | 25 ± 7.6 (n = 5) | <18 (n = 2) | 107 ± 35** (n = 5) |
24 ± 5.1 (n = 6) | 51 ± 48 (n = 5) | 63 ± 46 (n = 2) |