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Table 5 Blood urea nitrogen and creatinine levels in blood plasma of mice injected with 161Tb-folate or 177Lu-folate

From: Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of 161Tb-folate and 177Lu-folate

 

Control

161Tb-folate

177Lu-folate

Week

Group A

Group B: 10 MBq

Group C: 20 MBq

Group D: 30 MBq

Group E: 10 MBq

Group F: 20 MBq

Group G: 30 MBq

Blood urea nitrogen (mM)

8

8.8 ± 0.8 (n = 7)

9.0 ± 1.3 (n = 5)

8.6 ± 0.6 (n = 6)

14 ± 7.5* (n = 6)

11 ± 0.8 (n = 6)

8.3 ± 0.6 (n = 6)

8.8 ± 0.6 (n = 4)

19

9.8 ± 0.6 (n = 9)

9.4 ± 0.6 (n = 6)

11 ± 1.6 (n = 5)

23 (n = 1)

10 ± 0.7 (n = 6)

9.3 ± 2.5 (n = 6)

26 ± 13*** (n = 6)

26

8.5 ± 0.8 (n = 9)

8.6 ± 1.6 (n = 6)

16 ± 12 (n = 5)

n.d.

9.2 ± 0.5 (n = 5)

21 ± 7.2 (n = 5)

>50*** (n = 1)

Terminal

8.4 ± 1.4 (n = 9)

9.2 ± 3.0 (n = 6)

>50 (n = 1)

>50 (n = 2)

10 ± 2.6 (n = 5)

38 ± 4.1*** (n = 4)

>50*** (n = 5)

13 ± 3.2 (n = 5)

42 ± 8.1*** (n = 4)

Creatinine (μM)

8

<18 (n = 3)

<18 (n = 3)

<18 (n = 6)

<18 (n = 1)

<18 (n = 3)

<18 (n = 3)

<18 (n = 4)

21 ± 3.5 (n = 4)

32 ± 1.4 (n = 2)

31 ± 14 (n = 5)

20 ± 1.0 (n = 3)

18 (n = 1)

19

26 ± 9.6 (n = 8)

<18 (n = 2)

<18 (n = 3)

32 (n = 1)

<18 (n = 3)

<18 (n = 2)

25 ± 6.3 (n = 6)

25 ± 7.3 (n = 4)

21 ± 4.9 (n = 2)

22 ± 0.6 (n = 3)

18 ± 0 (n = 3)

26

<18 (n = 4)

<18 (n = 4)

<18 (n = 2)

n.d.

30 ± 19 (n = 5)

33 ± 7.6 (n = 5)

46 (n = 1)

 

20 ± 1.7 (n = 4)

22 ± 0.7 (n = 2)

33 ± 5.9 (n = 3)

Terminal

<18 (n = 3)

21 ± 3.8 (n = 6)

<18 (n = 1)

77 ± 17* (n = 6)

25 ± 7.6 (n = 5)

<18 (n = 2)

107 ± 35** (n = 5)

24 ± 5.1 (n = 6)

51 ± 48 (n = 5)

63 ± 46 (n = 2)

  1. The blood plasma parameters were determined in Week 8, 19, 26 and before euthanasia (terminal)
  2. Abbreviations: n.d. not determined (already euthanized), n number of mice
  3. Statistics: comparison of treated animals to control; *P < 0.05, **P < 0.01, ***P < 0.001
  4. Detection limits: blood urea nitrogen: 50 mM; creatinine: 18 μM