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Table 2 Histological partial scoring, with each compartment (glomeruli, tubules, interstitium) evaluated separately

From: Contribution of Auger/conversion electrons to renal side effects after radionuclide therapy: preclinical comparison of 161Tb-folate and 177Lu-folate

Partial score Pathological changes
1 Glomeruli: mild deposition of PTAH-positive eosinophilic material (fibrin) and reduced number of capillaries in a few glomeruli.
Tubules: <10 % of cortical tubules collapsed or degenerated.
Interstitium: few small mononuclear cell infiltrates and/or minimal fibrosis in the cortex.
2 Glomeruli: mild/moderate fibrin deposition and reduced number of capillaries in numerous glomeruli.
Tubules: 10–25 % of cortical tubules collapsed or degenerated.
Interstitium: multifocal small mononuclear cell infiltrates and/or mild fibrosis in the cortex.
3 Glomeruli: marked fibrin deposition and reduced number of capillaries in numerous glomeruli.
Tubules: 25–50 % of cortical tubules collapsed or degenerated.
Interstitium: multifocal larger mononuclear cell infiltrates and/or moderate fibrosis in the cortex.
4 Glomeruli: marked fibrin deposition and reduced number of capillaries in numerous glomeruli; glomerulosclerosis in a few to several glomeruli.
Tubules: 50–75 % of cortical tubules collapsed or degenerated; numerous dilated tubules.
Interstitium: multifocal larger mononuclear cell infiltrates and/or moderate fibrosis in the cortex and medulla; mild/moderate parenchymal collapse.
5 Glomeruli: majority of glomeruli sclerotic.
Tubules: >75 % of cortical tubules collapsed or degenerated; numerous dilated tubules.
Interstitium: severe parenchymal collapse, affecting cortex and medulla.