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EJNMMI Research
Fig. 3 | EJNMMI Research

Fig. 3

From: Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Fig. 3

In vivo PET images of [11C]TASP0410457, [11C]TASP0434988, and [11C]TASP0390136 in the rat brain. Average sagittal PET images at 0–90 min after intravenous administration of [11C]TASP0410457 (top), [11C]TASP0434988 (middle), and [11C]TASP0390136 (bottom) at baseline (a–c) and after pretreatment with 10 mg/kg of thioperamide (d–f). The PET images were overlaid on an MRI template

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