Skip to main content
EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization

Fig. 1

Use of a combination of two tumour-specific VHHs for optical imaging results in higher T/B ratios. a Optical imaging of mice xenografted with MCF10DCIS cells in time upon injection of the combination 11A4-800 and B9-800 (upper panel) and the control combinations, 11A4-800 and R2-800 (middle panel) or B9-800 and R2-800 (bottom panel). Arrows point to tumours, bl depicts bladder. b T/B ratios in time (n = 7 per group). Graph represents mean ± SEM. These were calculated from ROIs drawn around each tumour and non-tumour area. c Comparison of overall T/B ratios and their SEM obtained at all time points for animals injected with B9-800 and 11A4-800 and the controls: B9-800 and R2-800 or 11A4-800 and R2-800. The p values were determined, and statistical significance is indicated by * when p < 0.05, ** when p < 0.01 and *** when p < 0.0001

Back to article page