Table 6 Ratios between bone and soft tissue after 8 days p.i. of 177Lu-complexes in Wistar rats
From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
Bone/organ | [177Lu]citrate | [177Lu]BPAMD | [177Lu]BPAPD | [177Lu]BPPED | [177Lu]NO2APBP | [177Lu]DO2A(PBP)2 | [177Lu]DOTA(MBP)2 |
|---|---|---|---|---|---|---|---|
Blood | n.d. | 6703 | n.d. | 5123 | n.d. | n.d. | 2639 |
Brain | n.d. | 1405 | n.d. | 365 | n.d. | n.d. | 419 |
Pancreas | n.d. | 851 | n.d. | 1104 | n.d. | n.d. | 110 |
Spleen | n.d. | 257 | n.d. | 246 | n.d. | n.d. | 11 |
Adrenal gland | n.d. | 547 | n.d. | 159 | n.d. | n.d. | 44 |
Kidneys | n.d. | 66 | n.d. | 59 | n.d. | n.d. | 20 |
Adipose tissue | n.d. | 1158 | n.d. | 1231 | n.d. | n.d. | 287 |
Muscle | n.d. | 37 | n.d. | 192 | n.d. | n.d. | 312 |
Heart | n.d. | 885 | n.d. | 653 | n.d. | n.d. | 74 |
Lung | n.d. | 634 | n.d. | 637 | n.d. | n.d. | 63 |
Thymus | n.d. | 787 | n.d. | 933 | n.d. | n.d. | 67 |
Harderian gland | n.d. | 48 | n.d. | 46 | n.d. | n.d. | 22 |
Liver | n.d. | 203 | n.d. | 189 | n.d. | n.d. | 16 |
Testes | n.d. | 1136 | n.d. | 1214 | n.d. | n.d. | 148 |