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Table 6 Ratios between bone and soft tissue after 8 days p.i. of 177Lu-complexes in Wistar rats

From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Bone/organ [177Lu]citrate [177Lu]BPAMD [177Lu]BPAPD [177Lu]BPPED [177Lu]NO2APBP [177Lu]DO2A(PBP)2 [177Lu]DOTA(MBP)2
Blood n.d. 6703 n.d. 5123 n.d. n.d. 2639
Brain n.d. 1405 n.d. 365 n.d. n.d. 419
Pancreas n.d. 851 n.d. 1104 n.d. n.d. 110
Spleen n.d. 257 n.d. 246 n.d. n.d. 11
Adrenal gland n.d. 547 n.d. 159 n.d. n.d. 44
Kidneys n.d. 66 n.d. 59 n.d. n.d. 20
Adipose tissue n.d. 1158 n.d. 1231 n.d. n.d. 287
Muscle n.d. 37 n.d. 192 n.d. n.d. 312
Heart n.d. 885 n.d. 653 n.d. n.d. 74
Lung n.d. 634 n.d. 637 n.d. n.d. 63
Thymus n.d. 787 n.d. 933 n.d. n.d. 67
Harderian gland n.d. 48 n.d. 46 n.d. n.d. 22
Liver n.d. 203 n.d. 189 n.d. n.d. 16
Testes n.d. 1136 n.d. 1214 n.d. n.d. 148
  1. n.d. data not determined