From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
Organ | [177Lu]citrate | [177Lu]BPAMD | [177Lu]BPAPD | [177Lu]BPPED | [177Lu]NO2APBP | [177Lu]DO2A(PBP)2 | [177Lu]DOTA(MBP)2 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
Blood | n.d. | n.d. | 0.90 | 0.42 | 0.84 | 0.07 | 1.30 | 0.20 | 2.08 | 2.83 | 3.35 | 0.33 | 3.98 | 0.40 |
Brain | n.d. | n.d. | 0.04 | 0.01 | 0.05 | 0.02 | 0.04 | 0.01 | 0.04 | 0.01 | 0.09 | 0.01 | 0.13 | 0.03 |
Pancreas | n.d. | n.d. | 0.31 | 0.14 | 1.60 | 1.18 | 0.37 | 0.12 | 0.27 | 0.08 | 0.73 | 0.15 | 0.68 | 0.14 |
Spleen | n.d. | n.d. | 0.37 | 0.35 | 1.27 | 0.94 | 0.39 | 0.05 | 0.23 | 0.03 | 0.60 | 0.13 | 0.78 | 0.10 |
Adrenal gland | n.d. | n.d. | 0.40 | 0.13 | 0.55 | 0.17 | 0.70 | 0.41 | 0.60 | 0.42 | 1.23 | 0.19 | 1.07 | 0.19 |
Kidneys | n.d. | n.d. | 4.53 | 4.01 | 3.61 | 1.81 | 3.09 | 0.48 | 3.08 | 1.14 | 2.87 | 0.29 | 3.10 | 0.54 |
Adipose tissue | n.d. | n.d. | 0.42 | 0.19 | 1.80 | 0.78 | 0.24 | 0.07 | 0.53 | 0.14 | 1.52 | 0.50 | 0.55 | 0.13 |
Muscle | n.d. | n.d. | 0.19 | 0.08 | 0.78 | 0.70 | 0.24 | 0.03 | 0.21 | 0.05 | 0.49 | 0.30 | 0.49 | 0.11 |
Heart | n.d. | n.d. | 0.36 | 0.14 | 0.36 | 0.04 | 0.52 | 0.10 | 0.31 | 0.06 | 1.34 | 0.17 | 1.45 | 0.30 |
Lung | n.d. | n.d. | 0.61 | 0.24 | 0.61 | 0.07 | 0.75 | 0.08 | 0.50 | 0.05 | 1.87 | 0.41 | 2.04 | 0.32 |
Thymus | n.d. | n.d. | 0.29 | 0.11 | 0.30 | 0.06 | 0.38 | 0.08 | 0.22 | 0.04 | 0.76 | 0.09 | 0.93 | 0.14 |
Harderian gland | n.d. | n.d. | 0.36 | 0.13 | 0.37 | 0.10 | 0.40 | 0.12 | 0.35 | 0.08 | 0.95 | 0.23 | 1.12 | 0.16 |
Liver | n.d. | n.d. | 0.26 | 0.11 | 0.39 | 0.08 | 0.48 | 0.12 | 0.29 | 0.12 | 1.07 | 0.15 | 1.13 | 0.39 |
Testes | n.d. | n.d. | 0.25 | 0.07 | 0.28 | 0.03 | 0.36 | 0.01 | 0.32 | 0.05 | 0.24 | 0.02 | 0.30 | 0.03 |
Femur | n.d. | n.d. | 3.36 | 0.63 | 3.43 | 0.44 | 4.16 | 0.35 | 2.67 | 0.04 | 2.11 | 0.22 | 2.31 | 0.15 |