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Table 1 Biodistribution of radioactivity after 5 min p.i. of 177Lu-complexes in Wistar rats

From: 177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

Organ [177Lu]citrate [177Lu]BPAMD [177Lu]BPAPD [177Lu]BPPED [177Lu]NO2APBP [177Lu]DO2A(PBP)2 [177Lu]DOTA(MBP)2
Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD Mean SD
Blood n.d. n.d. 0.90 0.42 0.84 0.07 1.30 0.20 2.08 2.83 3.35 0.33 3.98 0.40
Brain n.d. n.d. 0.04 0.01 0.05 0.02 0.04 0.01 0.04 0.01 0.09 0.01 0.13 0.03
Pancreas n.d. n.d. 0.31 0.14 1.60 1.18 0.37 0.12 0.27 0.08 0.73 0.15 0.68 0.14
Spleen n.d. n.d. 0.37 0.35 1.27 0.94 0.39 0.05 0.23 0.03 0.60 0.13 0.78 0.10
Adrenal gland n.d. n.d. 0.40 0.13 0.55 0.17 0.70 0.41 0.60 0.42 1.23 0.19 1.07 0.19
Kidneys n.d. n.d. 4.53 4.01 3.61 1.81 3.09 0.48 3.08 1.14 2.87 0.29 3.10 0.54
Adipose tissue n.d. n.d. 0.42 0.19 1.80 0.78 0.24 0.07 0.53 0.14 1.52 0.50 0.55 0.13
Muscle n.d. n.d. 0.19 0.08 0.78 0.70 0.24 0.03 0.21 0.05 0.49 0.30 0.49 0.11
Heart n.d. n.d. 0.36 0.14 0.36 0.04 0.52 0.10 0.31 0.06 1.34 0.17 1.45 0.30
Lung n.d. n.d. 0.61 0.24 0.61 0.07 0.75 0.08 0.50 0.05 1.87 0.41 2.04 0.32
Thymus n.d. n.d. 0.29 0.11 0.30 0.06 0.38 0.08 0.22 0.04 0.76 0.09 0.93 0.14
Harderian gland n.d. n.d. 0.36 0.13 0.37 0.10 0.40 0.12 0.35 0.08 0.95 0.23 1.12 0.16
Liver n.d. n.d. 0.26 0.11 0.39 0.08 0.48 0.12 0.29 0.12 1.07 0.15 1.13 0.39
Testes n.d. n.d. 0.25 0.07 0.28 0.03 0.36 0.01 0.32 0.05 0.24 0.02 0.30 0.03
Femur n.d. n.d. 3.36 0.63 3.43 0.44 4.16 0.35 2.67 0.04 2.11 0.22 2.31 0.15
  1. Data are expressed in SUV. Each value represents the mean (S.D.) of four animals
  2. n.d. data not determined