Fig. 4
a Uptake of [111In-DOTA]MG11 in kidneys and A431-CCK2R(+) and A431-CCK2R(−) tumors at 4 h pi in SCID mice for controls and increasing amounts of the NEP inhibitors TO and PA. Data are given as mean of %ID/g ± SD, n ≥ 4. [111In-DOTA]MG11 iv-coinjection with vehicle (
), with 1.5 μg TO (
), with 15 μg TO (
), with 150 μg TO (
), with 3 μg PA (
), with 30 μg PA (
), or 300 μg PA (
) in SCID mice bearing twin A431-CCK2R(+) (Tu+) and naïve A431-CCK2R(−) (Tu−) human xenografts. b Corresponding tumor-to-kidney ratios (Tu/Ki)