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Table 1 Protein binding (n = 6) and stability (n = 3) values after 30, 60 and 120 min incubation at RT for 68Ga- and 177Lu-labelled compounds

From: Influence of a novel, versatile bifunctional chelator on theranostic properties of a minigastrin analogue

Incubation time [min] A [%] B [%] C [%] D [%]
68Ga 177Lu 68Ga 177Lu 68Ga 177Lu 68Ga 177Lu
30 9.5 ± 0.4 4.9 ± 0.7 96 ± 2.1 99 ± 0.27 94 ± 1.6 92 ± 0.24 90 ± 3.2 97 ± 0.47
60 13.0 ± 1.2 4.9 ± 1.0 95 ± 2.7 98 ± 0.24 91 ± 1.6 87 ± 0.31 88 ± 2.1 98 ± 0.12
120 15.8 ± 1.8 3.7 ± 0.8 92 ± 5.5 98 ± 0.12 90 ± 0.5 77 ± 0.72 81 ± 7.9 97 ± 2.12
  1. Data are shown as means ± SD
  2. A serum protein binding; B stability in EDTA solution; C stability in DTPA solution; D stability in fresh human serum