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EJNMMI Research
Fig. 1 | EJNMMI Research

Fig. 1

From: Modeling [18F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge

Fig. 1

Measurement of image-derived input function. a, b SUV [18F]-FDG-PET images reconstructed 6 min (360 s) after [18F]-FDG bolus injection showing high concentrations of radiotracer in the arterial blood. Black circles on the images show the location of the VOIs, 2-mm spheres, in the arch of aorta, sagittal view (a), and the left ventricle, coronal view (b). c, d The kinetics of [18F]-FDG SUV in the arterial blood was determined in the left ventricle (blue line) and in the arch of aorta (green line), and the average of SUVs from these two sites is shown by the orange line in two animals. Inserts show SUVs from the subject and average of the two sites in the first 203 s after [18F]-FDG injection. e Two-tissue compartment kinetic model with irreversible tracer. C a (t) is the concentration of the tracer in arterial blood, C e (t) is the concentration of the tracer in extracellular space, and C m (t) is the concentration of the phosphorylated [18F]-FDG in the tissue. Abbreviations: FDG, fluorodeoxyglucose; VOI, volume of interest

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