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Table 1 Number of regulated genes in thyroid tissue in mice 1–168 h after administration of 131I and 211At

From: Gene expression signature in mouse thyroid tissue after 131I and 211At exposure

Radionuclide Δt (h) A (kBq) D (Gy) Mice (n) Regulated genes (no.)
Total Up Down
211At 1 1.7 0.023 3 210 92 118
   100 1.4 3 630 345 285
  6 1.7 0.32 3 170 51 119
   7.5 1.4 3 290 116 174
  24 0.064 0.05 3 360 254 106
   0.64 0.5 3 157 95 62
   1.7 1.4 3 359 149 210
   14 11 3 464 339 125
   42 32 3 357 251 106
  168 1.7 1.8 3 136 49 87
131I 24 13 0.85 2 227 101 126
   130 8.5 2 266 138 128
   260 17 2 55 37 18
  1. Absorbed dose was calculated using MIRD formalism
  2. Abbreviations: Δt exposure time, A injected activity, D absorbed dose