Table 1 Number of regulated genes in thyroid tissue in mice 1–168 h after administration of 131I and 211At
From: Gene expression signature in mouse thyroid tissue after 131I and 211At exposure
Radionuclide | Δt (h) | A (kBq) | D (Gy) | Mice (n) | Regulated genes (no.) | ||
|---|---|---|---|---|---|---|---|
Total | Up | Down | |||||
211At | 1 | 1.7 | 0.023 | 3 | 210 | 92 | 118 |
| Â | Â | 100 | 1.4 | 3 | 630 | 345 | 285 |
| Â | 6 | 1.7 | 0.32 | 3 | 170 | 51 | 119 |
| Â | Â | 7.5 | 1.4 | 3 | 290 | 116 | 174 |
| Â | 24 | 0.064 | 0.05 | 3 | 360 | 254 | 106 |
| Â | Â | 0.64 | 0.5 | 3 | 157 | 95 | 62 |
| Â | Â | 1.7 | 1.4 | 3 | 359 | 149 | 210 |
| Â | Â | 14 | 11 | 3 | 464 | 339 | 125 |
| Â | Â | 42 | 32 | 3 | 357 | 251 | 106 |
| Â | 168 | 1.7 | 1.8 | 3 | 136 | 49 | 87 |
131I | 24 | 13 | 0.85 | 2 | 227 | 101 | 126 |
| Â | Â | 130 | 8.5 | 2 | 266 | 138 | 128 |
| Â | Â | 260 | 17 | 2 | 55 | 37 | 18 |