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Table 3 Method III—multiple of liver mean activity + 2 × standard deviation (SD))

From: Optimal definition of biological tumor volume using positron emission tomography in an animal model

Multiple of liver mean

Sensitivity (CI)

Specificity (CI)

GTAOE/WTAH (CI)

1.5

100.0 % (100.0–100.0 %)

11.9 % (6.9–17.7 %)

50.5 % (42.7–59.1 %)

3

99.9 % (99.7–100.0 %)

36.9 % (26.8–47.1 %)

24.4 % (20.0–29.2 %)

4

99.3 % (98.8–99.6 %)

50.8 % (40.4–60.6 %)

16.2 % (13.0–19.8 %)

5

97.8 % (96.8–98.6 %)

62.1 % (53.0–70.7 %)

11.1 % (8.7–13.9 %)

6

95.1 % (93.5–96.5 %)

71.2 % (63.4–78.5 %)

7.4 % (5.6–9.5 %)

7

90.7 % (88.1–93.2 %)

78.1 % (71.5–84.3 %)

5.1 % (3.7–6.9 %)

  1. CI confidence interval, GTA OE gross tumor area overestimate, WTA H whole tumor areas on histology