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Table 2 Statistical evaluation of the change in immune cell marker positive cells after administration of RIT. The number of antigen-positive cells at day 0 and the average change in positive cells within tumors treated with RIT (% per day, confidence interval and p value) at different localizations

From: Evaluation of immune cell markers in tumor tissue treated with radioimmunotherapy in an immunocompetent rat colon carcinoma model

Antigen Localization Positive cells on day 0 median (range) Average change after admin. of radioimmunoconjugate (95 % confidence interval) p value
CD2 Tumor cell areas 20 (0–80) −30 % per day (−48 to −5.5) 0.022
Granulation tissue between tumor cell areas 240 (110–450) −33 % per day (−51 to −8.2) 0.015
Granulation tissue surrounding tumor cell areas 370 (110–370) −36 % per day (−52 to −15) 0.003
CD3 Tumor cell areas 50 (0–150) −36 % per day (−49 to −18) 0.001
Granulation tissue between tumor cell areas 350 (150–570) −24 % per day (−30 to +17) <0.001
Granulation tissue surrounding tumor cell areas 480 (130–910) −29 % per day (−36 to −20) <0.001
CD8α Tumor cell areas 90 (30–180) −10 % per day (−29 to +13) 0.35
Granulation tissue between tumor cell areas 260 (80–490) −0.1 % per day (−4.4 to +4.9) 0.95
Granulation tissue surrounding tumor cell areas 340 (180–530) −4.7 % per day (−8.8 to +0.41) 0.033
CD68 Tumor cell areas 310 (130–640) −1.3 per day (−11 to +9.7) 0.80
Granulation tissue between tumor cell areas 510 (310–710) +1.1 % per day (−2.8 to +5.3) 0.56
Granulation tissue surrounding tumor cell areas 560 (200–910) −9.7 % per day (−14 to −5.1) <0.001
CD163 Tumor cell areas 160 (60–380) −13 % per day (−26 to +0.47) 0.057
Granulation tissue between tumor cell areas 190 (110–310) +1.1 % per day (−2.8 to +5.3) 0.56
Granulation tissue surrounding tumor cell areas 200 (100–380) −4.2 % per day (−9.7 to +1.5) 0.14