Table 2 Statistical evaluation of the change in immune cell marker positive cells after administration of RIT. The number of antigen-positive cells at day 0 and the average change in positive cells within tumors treated with RIT (% per day, confidence interval and p value) at different localizations
Antigen | Localization | Positive cells on day 0 median (range) | Average change after admin. of radioimmunoconjugate (95 % confidence interval) | p value |
|---|---|---|---|---|
CD2 | Tumor cell areas | 20 (0–80) | −30 % per day (−48 to −5.5) | 0.022 |
Granulation tissue between tumor cell areas | 240 (110–450) | −33 % per day (−51 to −8.2) | 0.015 | |
Granulation tissue surrounding tumor cell areas | 370 (110–370) | −36 % per day (−52 to −15) | 0.003 | |
CD3 | Tumor cell areas | 50 (0–150) | −36 % per day (−49 to −18) | 0.001 |
Granulation tissue between tumor cell areas | 350 (150–570) | −24 % per day (−30 to +17) | <0.001 | |
Granulation tissue surrounding tumor cell areas | 480 (130–910) | −29 % per day (−36 to −20) | <0.001 | |
CD8α | Tumor cell areas | 90 (30–180) | −10 % per day (−29 to +13) | 0.35 |
Granulation tissue between tumor cell areas | 260 (80–490) | −0.1 % per day (−4.4 to +4.9) | 0.95 | |
Granulation tissue surrounding tumor cell areas | 340 (180–530) | −4.7 % per day (−8.8 to +0.41) | 0.033 | |
CD68 | Tumor cell areas | 310 (130–640) | −1.3 per day (−11 to +9.7) | 0.80 |
Granulation tissue between tumor cell areas | 510 (310–710) | +1.1 % per day (−2.8 to +5.3) | 0.56 | |
Granulation tissue surrounding tumor cell areas | 560 (200–910) | −9.7 % per day (−14 to −5.1) | <0.001 | |
CD163 | Tumor cell areas | 160 (60–380) | −13 % per day (−26 to +0.47) | 0.057 |
Granulation tissue between tumor cell areas | 190 (110–310) | +1.1 % per day (−2.8 to +5.3) | 0.56 | |
Granulation tissue surrounding tumor cell areas | 200 (100–380) | −4.2 % per day (−9.7 to +1.5) | 0.14 |