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Fig. 4 | EJNMMI Research

Fig. 4

From: Radioiodinated PARP1 tracers for glioblastoma imaging

Fig. 4

In vitro competitive inhibition of PARPi-FL uptake in U87 MG cells with the different iodo-PARPi derivatives. a Representative confocal images of cells stained with PARPi-FL (green) and Hoechst 33342 (blue) alone (left) or stained with PARPi-FL (250 nM) and Hoechst 33342 after addition of iodo-PARPi (25 μM) (right). b Effectiveness of the iodo-PARPi inhibitors to saturate PARP1, measured in % unblocked of each iodo-PARPi derivative along with the PARP1 inhibitor Olaparib

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