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Table 1 Comparison of sigma-1 receptor ligand binding affinities to S1R, S2R, and VAChT

From: Further validation to support clinical translation of [18F]FTC-146 for imaging sigma-1 receptors

 
  FTC-146 (−)-Vesamicol SN-56 SA4503 FPS Fluspidine
S1R K 1 (nM) 0.0025 74 [24] 0.56 4.6 4.3 [17] 0.59 [18]
S2R K 1 (nM) 364 364 [24] >1000 63 142 [17] 708 [18]
VAChT K 1 (nM) 450 20 140 50 N/A 1400 [18]