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Table 4 Ex vivo uptake of the evaluated tracers in brain regions and skull bones of rats

From: Synthesis and evaluation in rats of homologous series of [18F]-labeled dopamine D2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers

Tracer [18F]FEt-AMC13 [18F]FBu-AMC13 [18F]FEt-AMC15
Treatment Saline Raclopride Saline Raclopride Saline Raclopride
Region (n = 4) (n = 4) (n = 3) (n = 3) (n = 3) (n = 3)
Striatum 0.28 ± 0.03 (1) 0.23 ± 0.08 1.60 ± 0.33 (5) 1.21 ± 0.14 0.02 ± 0.02 0.03 ± 0.01
Hippocampus 0.22 ± 0.02 (2) 0.23 ± 0.08 1.50 ± 0.25 (6) 1.21 ± 0.06 0.03 ± 0.02 0.03 ± 0.01
Thalamus + hypothalamus 0.19 ± 0.003 (4) 0.19 ± 0.05 2.07 ± 0.70 (1) 1.07 ± 0.10 0.03 ± 0.01 0.03 ± 0.01
Cortex 0.18 ± 0.01 (5) 0.16 ± 0.04 1.50 ± 0.32 (7) 1.01 ± 0.11 0.03 ± 0.003 0.03 ± 0.01
Brainstem 0.18 ± 0.02 (6) 0.16 ± 0.04 1.97 ± 0.42 (2) 1.25 ± 0.14 0.03 ± 0.004 0.03 ± 0.01
Olfactory bulbs 0.17 ± 0.01 (7) 0.15 ± 0.04 1.85 ± 0.64 (3) 0.86 ± 0.09 0.03 ± 0.001 0.03 ± 0.02
Rest of brain 0.20 ± 0.02 (3) 0.18 ± 0.03 1.60 ± 0.25 (4) 1.10 ± 0.17 0.02 ± 0.02 0.03 ± 0.02
Cerebellum 0.13 ± 0.01 (8) 0.13 ± 0.02 1.11 ± 0.29 (8) 0.73 ± 0.08 0.03 ± 0.01 0.03 ± 0.01
Mean brain uptake 0.18 ± 0.01 0.16 ± 0.04 1.56 ± 0.33 1.03 ± 0.11 0.03 ± 0.01 0.03 ± 0.01
Pituitary 0.76 ± 0.08 0.59 ± 0.20 3.19 ± 0.29 2.72 ± 0.77 1.36 ± 0.30 1.08 ± 0.27
Parietal bone 0.10 ± 0.01 0.10 ± 0.01 0.61 ± 0.17 0.70 ± 0.18 0.09 ± 0.03 0.08 ± 0.03
  1. Data are presented as means ± standard deviations of standard uptake values. The ranking of the uptake magnitude (highest to lowest) among brain regions within the BBB is shown in parentheses (only for [18F]AMC13 homologues)