Tracer
|
[18F]FEt-AMC13
|
[18F]FBu-AMC13
|
[18F]FEt-AMC15
|
---|
Treatment
|
Saline
|
Raclopride
|
Saline
|
Raclopride
|
Saline
|
Raclopride
|
---|
Region
|
(n = 4)
|
(n = 4)
|
(n = 3)
|
(n = 3)
|
(n = 3)
|
(n = 3)
|
---|
Striatum
|
0.28 ± 0.03 (1)
|
0.23 ± 0.08
|
1.60 ± 0.33 (5)
|
1.21 ± 0.14
|
0.02 ± 0.02
|
0.03 ± 0.01
|
Hippocampus
|
0.22 ± 0.02 (2)
|
0.23 ± 0.08
|
1.50 ± 0.25 (6)
|
1.21 ± 0.06
|
0.03 ± 0.02
|
0.03 ± 0.01
|
Thalamus + hypothalamus
|
0.19 ± 0.003 (4)
|
0.19 ± 0.05
|
2.07 ± 0.70 (1)
|
1.07 ± 0.10
|
0.03 ± 0.01
|
0.03 ± 0.01
|
Cortex
|
0.18 ± 0.01 (5)
|
0.16 ± 0.04
|
1.50 ± 0.32 (7)
|
1.01 ± 0.11
|
0.03 ± 0.003
|
0.03 ± 0.01
|
Brainstem
|
0.18 ± 0.02 (6)
|
0.16 ± 0.04
|
1.97 ± 0.42 (2)
|
1.25 ± 0.14
|
0.03 ± 0.004
|
0.03 ± 0.01
|
Olfactory bulbs
|
0.17 ± 0.01 (7)
|
0.15 ± 0.04
|
1.85 ± 0.64 (3)
|
0.86 ± 0.09
|
0.03 ± 0.001
|
0.03 ± 0.02
|
Rest of brain
|
0.20 ± 0.02 (3)
|
0.18 ± 0.03
|
1.60 ± 0.25 (4)
|
1.10 ± 0.17
|
0.02 ± 0.02
|
0.03 ± 0.02
|
Cerebellum
|
0.13 ± 0.01 (8)
|
0.13 ± 0.02
|
1.11 ± 0.29 (8)
|
0.73 ± 0.08
|
0.03 ± 0.01
|
0.03 ± 0.01
|
Mean brain uptake
|
0.18 ± 0.01
|
0.16 ± 0.04
|
1.56 ± 0.33
|
1.03 ± 0.11
|
0.03 ± 0.01
|
0.03 ± 0.01
|
Pituitary
|
0.76 ± 0.08
|
0.59 ± 0.20
|
3.19 ± 0.29
|
2.72 ± 0.77
|
1.36 ± 0.30
|
1.08 ± 0.27
|
Parietal bone
|
0.10 ± 0.01
|
0.10 ± 0.01
|
0.61 ± 0.17
|
0.70 ± 0.18
|
0.09 ± 0.03
|
0.08 ± 0.03
|
- Data are presented as means ± standard deviations of standard uptake values. The ranking of the uptake magnitude (highest to lowest) among brain regions within the BBB is shown in parentheses (only for [18F]AMC13 homologues)