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Table 3 Quantitative results of in vitro autoradiography

From: Synthesis and evaluation in rats of homologous series of [18F]-labeled dopamine D2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers

Tracer Tracer concentration, nMa Striatal SBRb (% change relative to control condition)
Control Raclopride GTP
[18F]FEt-AMC13 0.9 ± 0.7 (n = 3) 3.40 ± 1.25 0.63 ± 0.53 (−81%)* 0.66 ± 0.52 (−81%)*
[18F]FPr-AMC13 1.4 ± 1.6 (n = 3) 2.07 ± 1.06 0.41 ± 0.23 (−80%)* 0.42 ± 0.23 (−80%)*
[18F]FBu-AMC13c 0.2 (n = 1) 0.85 ± 0.23 0.10 ± 0.19 (−88%)* 0.20 ± 0.16 (−76%)*
4.5 ± 3.6 (n = 3) 0.19 ± 0.18 0.04 ± 0.22 (−79%)
[18F]FEt-AMC15c 5.8 ± 1.6 (n = 4) 1.64 ± 1.04 0.65 ± 0.37 (−60%)* 0.67 ± 0.28 (−59%)*
[18F]FPr-AMC15 5.0 ± 7.2 (n = 3) 1.01 ± 0.46 0.39 ± 0.22 (−61%)* 0.37 ± 0.24 (−63%)*
[18F]FBu-AMC15 2.3 ± 1.8 (n = 3) 0.69 ± 0.30 0.25 ± 0.23 (−64%)* 0.23 ± 0.23 (−67%)*
  1. *p < 0.05 relative to control values, 2-sided Welch test
  2. aConcentrations are means ± SD from n independent experiments
  3. bSpecific binding ratio (SBR) values are means ± SD from the total number of slides (3–28 per condition) assayed in all experiments
  4. cPublished earlier [24]