Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

EJNMMI Research

Table 8 Comparison of preclinical studies with the human effective dose (ED) estimates

PET tracer	Animal derived ED (mSv/MBq)	Human derived ED (mSv/MBq)	Reference
¹¹C-6-OH-BTA-1	0.0065^a	0.0045	Parsey 2005; Scheinin 2007 [17, 18]
¹¹C-MPGA	0.0048	0.0053	Santens 1998 [19]
6-¹⁸ F-Fluoro-L-Dopa	0.0539^b	0.0199	Harvey 1985; Brown 1998 [20, 21]
¹⁸ F-FET	0.0186	0.0165	Tang 2003; Pauleit 2003 [22, 23]
¹¹C-Choline	0.0028	0.0044	Tolvanen 2010 [24]

^aMales only
^bED value calculated with the biological risk weight factors in accordance with ICRP 30 publication