Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

Autio, Anu; Virtanen, Helena; Tolvanen, Tuula; Liljenbäck, Heidi; Oikonen, Vesa; Saanijoki, Tiina; Siitonen, Riikka; Käkelä, Meeri; Schüssele, Andrea; Teräs, Mika; Roivainen, Anne

doi:10.1186/s13550-015-0117-z

EJNMMI Research

Table 2 Tissue/organ weights and ex vivo biodistribution of ⁶⁸Ga/⁶⁸Ge generator eluate in male rats

From: Absorption, distribution and excretion of intravenously injected ⁶⁸Ge/⁶⁸Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

Tissue/organ	Weight (g)	5 min	30 min	60 min	120 min	180 min
Adrenal glands	0.040 ± 0.012	0.635 ± 0.404	0.303 ± 0.047	0.338 ± 0.040	0.355 ± 0.174	0.278 ± 0.011
Blood	^a	1.556 ± 0.476	1.119 ± 0.088	1.175 ± 0.128	0.970 ± 0.165	0.908 ± 0.157
Bone (femur, both)	^a	0.285 ± 0.100	0.387 ± 0.188	0.500 ± 0.176	0.657 ± 0.240	0.854 ± 0.256
Bone marrow (femur, both)	^a	0.494 ± 0.061	0.354 ± 0.020	0.423 ± 0.066	0.394 ± 0.123	0.490 ± 0.064
Brain	1.633 ± 0.163	0.078 ± 0.020	0.041 ± 0.003	0.048 ± 0.006	0.034 ± 0.002	0.035 ± 0.007
Brown adipose tissue	^a	0.294 ± 0.099	0.279 ± 0.122	0.318 ± 0.075	0.255 ± 0.071	0.217 ± 0.070
Colon (without contents)	1.223 ± 0.424	0.230 ± 0.018	0.260 ± 0.048	0.285 ± 0.038	0.227 ± 0.077	0.305 ± 0.066
Fat (intraperitoneal)	^a	0.050 ± 0.019	0.069 ± 0.013	0.090 ± 0.031	0.069 ± 0.046	0.053 ± 0.009
Heart	1.086 ± 0.113	0.494 ± 0.075	0.338 ± 0.070	0.320 ± 0.032	0.270 ± 0.053	0.251 ± 0.042
Ileum (without contents)	3.923 ± 1.768	0.205 ± 0.088	0.186 ± 0.022	0.268 ± 0.074	0.222 ± 0.114	0.308 ± 0.081
Kidneys	2.113 ± 0.279	0.993 ± 0.730	0.359 ± 0.070	0.404 ± 0.026	0.343 ± 0.119	0.397 ± 0.025
Liver	12.497 ± 1.444	1.044 ± 0.516	0.514 ± 0.195	0.770 ± 0.336	0.746 ± 0.421	0.498 ± 0.209
Lungs	1.277 ± 0.133	0.608 ± 0.028	0.479 ± 0.045	0.484 ± 0.196	0.455 ± 0.079	0.374 ± 0.037
Pancreas	1.307 ± 0.301	0.246 ± 0.042	0.207 ± 0.067	0.212 ± 0.031	0.181 ± 0.034	0.173 ± 0.016
Plasma	^a	3.481 ± 0.980	2.078 ± 0.194	2.162 ± 0.251	1.639 ± 0.259	1.544 ± 0.203
Salivary glands	0.596 ± 0.060	0.351 ± 0.079	0.304 ± 0.018	0.336 ± 0.058	0.331 ± 0.075	0.315 ± 0.034
Skeletal muscle	^a	0.085 ± 0.069	0.125 ± 0.036	0.142 ± 0.019	0.151 ± 0.028	0.123 ± 0.023
Skin	^a	0.124 ± 0.074	0.157 ± 0.060	0.248 ± 0.038	0.204 ± 0.054	0.219 ± 0.037
Spleen	0.864 ± 0.135	0.520 ± 0.114	0.383 ± 0.099	0.516 ± 0.193	0.582 ± 0.255	0.455 ± 0.129
Stomach (without contents)	1.403 ± 0.241	0.222 ± 0.045	0.227 ± 0.061	0.268 ± 0.036	0.250 ± 0.058	0.264 ± 0.048
Testes	3.509 ± 0.214	0.076 ± 0.054	0.075 ± 0.023	0.140 ± 0.020	0.175 ± 0.026	0.198 ± 0.018
Thymus	0.497 ± 0.088	0.190 ± 0.033	0.137 ± 0.055	0.182 ± 0.050	0.141 ± 0.051	0.154 ± 0.064
Thyroids	0.020 ± 0.007	0.536 ± 0.040	0.355 ± 0.057	0.403 ± 0.131	0.415 ± 0.106	0.370 ± 0.105
Urinary bladder (without contents)	0.070 ± 0.015	0.267 ± 0.177	0.553 ± 0.360	0.502 ± 0.191	0.478 ± 0.216	0.418 ± 0.259
Urine	^a	0.758 ± 0.727	1.342 ± 0.530	1.408 ± 0.736	3.111 ± 3.927	1.520 ± 0.894
Residual carcass	289.423 ± 45.504	0.177 ± 0.082	0.218 ± 0.051	0.207 ± 0.039	0.215 ± 0.048	0.206 ± 0.038

Results are expressed as percentage of injected radioactivity dose per gram of tissue (mean ± SD)
^aOf blood, bone, bone marrow, brown adipose tissue, fat, plasma, skeletal muscle, skin, and urine, only a small sample was taken and weighed. All other tissues/organs were measured in their entirety

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