Absorption, distribution and excretion of intravenously injected 68Ge/68Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

Autio, Anu; Virtanen, Helena; Tolvanen, Tuula; Liljenbäck, Heidi; Oikonen, Vesa; Saanijoki, Tiina; Siitonen, Riikka; Käkelä, Meeri; Schüssele, Andrea; Teräs, Mika; Roivainen, Anne

doi:10.1186/s13550-015-0117-z

EJNMMI Research

Table 1 Organ weights and ex vivo biodistribution of ⁶⁸Ga/⁶⁸Ge generator eluate in female rats

From: Absorption, distribution and excretion of intravenously injected ⁶⁸Ge/⁶⁸Ga generator eluate in healthy rats, and estimation of human radiation dosimetry

Tissue/organ	Weight (g)	5 min	30 min	60 min	120 min	180 min
Adrenal glands	0.067 ± 0.016	0.673 ± 0.111	0.603 ± 0.271	0.705 ± 0.264	0.567 ± 0.226	0.497 ± 0.184
Blood	^a	2.909 ± 0.272	2.509 ± 1.359	2.563 ± 0.909	2.128 ± 0.953	1.668 ± 0.428
Bone (femur, both)	^a	0.298 ± 0.071	0.589 ± 0.132	0.820 ± 0.396	1.001 ± 0.363	0.963 ± 0.370
Bone marrow (femur, both)	^a	0.586 ± 0.133	0.296 ± 0.051	0.705 ± 0.242	0.790 ± 0.366	0.710 ± 0.231
Brain	1.612 ± 0.103	0.075 ± 0.006	0.079 ± 0.040	0.084 ± 0.025	0.080 ± 0.041	0.052 ± 0.016
Brown adipose tissue	^a	0.405 ± 0.017	0.605 ± 0.229	0.471 ± 0.213	0.376 ± 0.201	0.316 ± 0.126
Colon (without contents)	1.069 ± 0.288	0.289 ± 0.095	0.668 ± 0.283	0.615 ± 0.337	0.531 ± 0.302	0.431 ± 0.277
Fat (intraperitoneal)	^a	0.058 ± 0.028	0.177 ± 0.093	0.145 ± 0.073	0.158 ± 0.151	0.099 ± 0.038
Heart	0.801 ± 0.049	0.723 ± 0.115	0.755 ± 0.462	0.617 ± 0.235	0.540 ± 0.204	0.439 ± 0.141
Ileum (without contents)	3.322 ± 1.420	0.271 ± 0.040	0.550 ± 0.191	0.465 ± 0.070	0.631 ± 0.426	0.520 ± 0.202
Kidneys	1.389 ± 0.162	0.773 ± 0.173	0.875 ± 0.328	0.823 ± 0.301	0.722 ± 0.324	0.679 ± 0.208
Liver	7.179 ± 0.836	1.225 ± 0.374	1.529 ± 0.450	1.490 ± 0.516	1.597 ± 0.627	1.178 ± 0.759
Lungs	1.117 ± 0.079	0.949 ± 0.212	1.078 ± 0.520	1.136 ± 0.379	0.894 ± 0.450	0.754 ± 0.268
Ovaries	0.135 ± 0.024	0.574 ± 0.174	0.784 ± 0.429	1.343 ± 1.257	0.782 ± 0.286	0.750 ± 0.124
Pancreas	1.180 ± 0.225	0.464 ± 0.283	0.389 ± 0.211	0.364 ± 0.174	0.331 ± 0.164	0.346 ± 0.233
Plasma	^a	5.083 ± 0.486	4.491 ± 2.419	4.451 ± 1.523	3.742 ± 1.602	2.865 ± 0.813
Salivary glands	0.496 ± 0.047	0.397 ± 0.099	0.630 ± 0.230	0.506 ± 0.178	0.485 ± 0.229	0.382 ± 0.165
Skeletal muscle	^a	0.132 ± 0.048	0.253 ± 0.080	0.214 ± 0.118	0.190 ± 0.078	0.143 ± 0.077
Skin	^a	0.096 ± 0.029	0.341 ± 0.142	0.312 ± 0.176	0.265 ± 0.089	0.263 ± 0.079
Spleen	0.687 ± 0.136	0.493 ± 0.137	0.836 ± 0.204	0.785 ± 0.269	0.687 ± 0.201	0.661 ± 0.258
Stomach (without contents)	1.184 ± 0.216	0.261 ± 0.060	0.384 ± 0.117	0.471 ± 0.196	0.441 ± 0.255	0.369 ± 0.159
Thymus	0.305 ± 0.082	0.234 ± 0.003	0.259 ± 0.143	0.225 ± 0.089	0.264 ± 0.193	0.181 ± 0.106
Thyroids	0.017 ± 0.005	0.516 ± 0.020	0.656 ± 0.327	0.607 ± 0.245	0.576 ± 0.347	0.473 ± 0.174
Urinary bladder (without contents)	0.068 ± 0.021	0.256 ± 0.080	0.442 ± 0.172	0.636 ± 0.311	0.734 ± 0.187	0.469 ± 0.187
Urine	^a	0.417 ± 0.134	13.162 ± 3.607	3.526 ± 1.783	5.228 ± 2.368	2.314 ± 0.981
Uterus	0.591 ± 0.153	0.361 ± 0.145	1.023 ± 0.482	1.149 ± 0.865	0.819 ± 0.553	0.941 ± 0.585
Residual carcass	208.418 ± 11.160	0.200 ± 0.010	0.318 ± 0.036	0.266 ± 0.025	0.269 ± 0.023	0.262 ± 0.029

Results are expressed as percentage of injected radioactivity dose per gram of tissue (mean ± SD)
^aOf blood, bone, bone marrow, brown adipose tissue, fat, plasma, skeletal muscle, skin, and urine, only a small sample was taken and weighed. All other tissues/organs were measured in their entirety

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