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Figure 4 | EJNMMI Research

Figure 4

From: Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer’s disease

Figure 4

MicroPET/CT imaging. APP/PS1 and WT mice (22.6 months old; n = 3; closely age-matched) were injected intravenously with HPLC-purified [18F]-7B (12.95 MBq). Representative PET static images of brain (axial and coronal view) were obtained from 1- to 75-min post-intravenous injection and co-registered with CT for an anatomical reference. (A) Axial and coronal images of the transgenic and wild-type mice post-intravenous injection of the radiotracer. (B) Axial and coronal images of the transgenic and wild-type mice 15- to 45-min post-intravenous injection of the radiotracer Left: APP/PS1 mouse; Right: WT mouse. Note consistent higher retention of [18F]-7B in the brains of APP/PS1 (Left) compared with WT counterpart (Right). APP, amyloid precursor protein; PS1, presenilin-1; WT, wild type.

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