Figure 6
Time-photon curve of doxorubicin in the 9-Gy-irradiated mouse and not-irradiated mouse. The accumulation of doxorubicin in the tumour site of the 9-Gy-irradiated mouse was around 4 to 4.5 (108 photons·s−1·cm−3) for approximately 120 min after administration and then washed out gradually. On the other hand, the accumulation of doxorubicin in the tumour site of the not-irradiated mouse was around 2 to 2.5(108 photons·s−1·cm−3) at 30 min after administration, which was significantly lower than that in the 9-Gy-irradiated mouse. The site was subjected to washout at 30 min after administration, although the degree of washout was significantly greater than that observed in the 9-Gy-irradiated mouse.