TACs of [
C]erlotinib (top) and [
F]afatinib (bottom) after tariquidar treatment. TACs are averaged over three animals. Mutations: A549 (wild type), H1975 (L858R/T790M), and HCC827 (exon 19 deletion). Tumor and background were manually outlined on the basis of an additional [18F]FDG scan, which was performed directly after the TKI-PET scan was finished.