Cyclosporin A, but not tacrolimus, negatively affects the hepatic extraction fraction of hepatobiliary scintigraphy in liver transplant recipients

EJNMMI Research

Table 2 Results of scintigraphic and biochemical parameters in CSA and TAC groups at 3-month control

Parameters (range, average ± SD)	Total (n = 39)	CSA at 3 months (n = 24)	TAC at 3 months (n = 15)	pvalue
HEF (%)	11 to 100	11 to 90	46 to 100	<0.0001
HEF (%)	55.6 ± 31.6	35.8 ± 21.2	87.3 ± 14.8	<0.0001
Bilirubin (μmol/l)	2.0 to 59.0	5.0 to 59.0	2.0 to 38.0	0.02
Ref: <26	14.6 ± 12.6	18.1 ± 13.5	8.9 ± 8.4	0.02
ALAT (μkat/l)	0.1 to 1.6	0.1 to 1.6	0.2 to 1.0	0.57
Ref: <0.76	0.6 ± 0.3	0.6 ± 0.4	0.5 ± 0.2	0.57
ASAT (μkat/l)	0.2 to 2.5	0.2 to 2.5	0.2 to 1.2	0.33
Ref: <0.61	0.6 ± 0.4	0.7 ± 0.5	0.5 ± 0.2	0.33
ALP (μkat/l)	0.8 to 18.1	0.8 to 5.8	0.8 to 18.1	0.16
Ref: <1.9	2.1 ± 2.9	1.6 ± 1.2	3.0 ± 4.4	0.16
GT (μkat/l)	0.3 to 22.7	0.3 to 8.8	0.4 to 22.7	0.16
Ref: <1.3	2.8 ± 4.6	2.0 ± 2.3	4.1 ± 6.7	0.16

CSA, cyclosporine A; TAC, tacrolimus; ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; ALP, alkaline phosphatase; GT, gamma-glutamyl transpeptidase.