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EJNMMI Research

Table 1 Comparison of regional uptake and binding potential in the different brain regions

From: ABC transporter-dependent brain uptake of the 5-HT1B receptor radioligand [11C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig

 

Mouse

Rat

Guinea pig

Baseline

CsA

Pvalue

Baseline

CsA

Pvalue

Baseline

CsA

Pvalue

%SUV

         

 Whole brain

33.4 ± 2.4

98.6 ± 10.8

0.0000

37.4 ± 4.1

119.0 ± 29.3

0.0002

259.6 ± 34.6

643.1 ± 192.4

0.0020

 Cortex

30.9 ± 2.6

95.1 ± 10.6

0.0000

38.7 ± 4.2

113.0 ± 26.7

0.0002

213.3 ± 27.3

566.9 ± 198.1

0.0027

 Striatum

28.6 ± 2.4

110.4 ± 12.1

0.0000

37.0 ± 5.8

146.9 ± 43.5

0.0003

394.4 ± 58.7

768.3 ± 299.9

0.0205

 Thalamus

29.3 ± 2.2

114.4 ± 14.1

0.0000

36.2 ± 5.3

145.5 ± 41.8

0.0003

301.5 ± 44.9

792.1 ± 216.4

0.0015

 Hypothalamus

40.3 ± 2.3

107.8 ± 10.3

0.0000

41.2 ± 5.9

143.6 ± 39.7

0.0003

354.9 ± 60.9

794.3 ± 204.1

0.0019

 Hippocampus

28.0 ± 2.2

102.6 ± 11.0

0.0000

35.6 ± 4.6

137.3 ± 40.1

0.0003

228.3 ± 31.7

605.7 ± 171.1

0.0011

 Central canal-PAG

27.1 ± 1.8

106.3 ± 13.4

0.0000

37.4 ± 5.3

147.4 ± 38.7

0.0002

446.2 ± 71.8

986.5 ± 248.0

0.0027

 Colliculus inferior

28.0 ± 2.6

107.1 ± 12.9

0.0000

36.7 ± 4.1

138.7 ± 38.0

0.0003

192.7 ± 30.3

900.5 ± 264.7

0.0005

 Colliculus superior

28.1 ± 2.9

94.1 ± 10.2

0.0000

34.4 ± 4.3

127.9 ± 32.2

0.0002

428.4 ± 69.7

1 072.5 ± 291.8

0.0018

 Midbrain

30.8 ± 2.4

111.5 ± 12.5

0.0000

37.4 ± 4.3

143.6 ± 36.7

0.0002

409.5 ± 67.6

970.1 ± 245.5

0.0018

 Cerebellum

33.7 ± 3.1

81.1 ± 8.6

0.0000

34.0 ± 3.3

96.4 ± 18.3

0.0001

162.7 ± 24.8

467.5 ± 135.8

0.0006

 Cerebellum GM

-

-

-

-

-

-

120.8 ± 17.4

372.6 ± 122.1

0.0009

BPND

         

 Whole brain

-

0.19 ± 0.04

n/a

-

0.21 ± 0.10

n/a

1.56 ± 0.39

1.57 ± 0.44

n.s.

 Cortex

-

0.12 ± 0.04

n/a

-

0.15 ± 0.10

n/a

1.00 ± 0.23

1.23 ± 0.30

n.s.

 Striatum

-

0.39 ± 0.08

n/a

-

0.48 ± 0.21

n/a

3.13 ± 0.90

2.36 ± 0.52

0.0224

 Thalamus

-

0.39 ± 0.16

n/a

-

0.48 ± 0.18

n/a

2.05 ± 0.55

2.29 ± 0.72

n.s.

 Hypothalamus

-

0.30 ± 0.06

n/a

-

0.45 ± 0.15

n/a

2.76 ± 0.74

2.81 ± 1.04

n.s.

 Hippocampus

-

0.25 ± 0.11

n/a

-

0.39 ± 0.18

n/a

1.25 ± 0.29

1.38 ± 0.38

n.s.

 Central canal-PAG

-

0.15 ± 0.17

n/a

-

0.50 ± 0.11

n/a

4.06 ± 1.36

5.00 ± 3.04

n.s.

 Colliculus inferior

-

0.17 ± 0.19

n/a

-

0.42 ± 0.12

n/a

3.08 ± 0.86

4.00 ± 1.54

n.s.

 Colliculus superior

-

0.13 ± 0.06

n/a

-

0.27 ± 0.14

n/a

3.50 ± 1.15

3.65 ± 1.11

n.s.

 Midbrain

-

0.26 ± 0.20

n/a

-

0.46 ± 0.11

n/a

3.34 ± 1.01

3.40 ± 1.17

n.s.

 Cerebellum

-

-

-

-

-

-

0.52 ± 0.16

0.49 ± 0.44

n.s.

  1. Regional uptake and binding potential of [11C]AZ10419369 in the different brain regions in mice, rats, and guinea pigs during baseline and CsA pretreatment conditions (each value represents mean ± SD). n/a, not applicable; n.s., not significant.
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