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Table 1 Comparison of regional uptake and binding potential in the different brain regions

From: ABC transporter-dependent brain uptake of the 5-HT1B receptor radioligand [11C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig

  Mouse Rat Guinea pig
Baseline CsA Pvalue Baseline CsA Pvalue Baseline CsA Pvalue
%SUV          
 Whole brain 33.4 ± 2.4 98.6 ± 10.8 0.0000 37.4 ± 4.1 119.0 ± 29.3 0.0002 259.6 ± 34.6 643.1 ± 192.4 0.0020
 Cortex 30.9 ± 2.6 95.1 ± 10.6 0.0000 38.7 ± 4.2 113.0 ± 26.7 0.0002 213.3 ± 27.3 566.9 ± 198.1 0.0027
 Striatum 28.6 ± 2.4 110.4 ± 12.1 0.0000 37.0 ± 5.8 146.9 ± 43.5 0.0003 394.4 ± 58.7 768.3 ± 299.9 0.0205
 Thalamus 29.3 ± 2.2 114.4 ± 14.1 0.0000 36.2 ± 5.3 145.5 ± 41.8 0.0003 301.5 ± 44.9 792.1 ± 216.4 0.0015
 Hypothalamus 40.3 ± 2.3 107.8 ± 10.3 0.0000 41.2 ± 5.9 143.6 ± 39.7 0.0003 354.9 ± 60.9 794.3 ± 204.1 0.0019
 Hippocampus 28.0 ± 2.2 102.6 ± 11.0 0.0000 35.6 ± 4.6 137.3 ± 40.1 0.0003 228.3 ± 31.7 605.7 ± 171.1 0.0011
 Central canal-PAG 27.1 ± 1.8 106.3 ± 13.4 0.0000 37.4 ± 5.3 147.4 ± 38.7 0.0002 446.2 ± 71.8 986.5 ± 248.0 0.0027
 Colliculus inferior 28.0 ± 2.6 107.1 ± 12.9 0.0000 36.7 ± 4.1 138.7 ± 38.0 0.0003 192.7 ± 30.3 900.5 ± 264.7 0.0005
 Colliculus superior 28.1 ± 2.9 94.1 ± 10.2 0.0000 34.4 ± 4.3 127.9 ± 32.2 0.0002 428.4 ± 69.7 1 072.5 ± 291.8 0.0018
 Midbrain 30.8 ± 2.4 111.5 ± 12.5 0.0000 37.4 ± 4.3 143.6 ± 36.7 0.0002 409.5 ± 67.6 970.1 ± 245.5 0.0018
 Cerebellum 33.7 ± 3.1 81.1 ± 8.6 0.0000 34.0 ± 3.3 96.4 ± 18.3 0.0001 162.7 ± 24.8 467.5 ± 135.8 0.0006
 Cerebellum GM - - - - - - 120.8 ± 17.4 372.6 ± 122.1 0.0009
BPND          
 Whole brain - 0.19 ± 0.04 n/a - 0.21 ± 0.10 n/a 1.56 ± 0.39 1.57 ± 0.44 n.s.
 Cortex - 0.12 ± 0.04 n/a - 0.15 ± 0.10 n/a 1.00 ± 0.23 1.23 ± 0.30 n.s.
 Striatum - 0.39 ± 0.08 n/a - 0.48 ± 0.21 n/a 3.13 ± 0.90 2.36 ± 0.52 0.0224
 Thalamus - 0.39 ± 0.16 n/a - 0.48 ± 0.18 n/a 2.05 ± 0.55 2.29 ± 0.72 n.s.
 Hypothalamus - 0.30 ± 0.06 n/a - 0.45 ± 0.15 n/a 2.76 ± 0.74 2.81 ± 1.04 n.s.
 Hippocampus - 0.25 ± 0.11 n/a - 0.39 ± 0.18 n/a 1.25 ± 0.29 1.38 ± 0.38 n.s.
 Central canal-PAG - 0.15 ± 0.17 n/a - 0.50 ± 0.11 n/a 4.06 ± 1.36 5.00 ± 3.04 n.s.
 Colliculus inferior - 0.17 ± 0.19 n/a - 0.42 ± 0.12 n/a 3.08 ± 0.86 4.00 ± 1.54 n.s.
 Colliculus superior - 0.13 ± 0.06 n/a - 0.27 ± 0.14 n/a 3.50 ± 1.15 3.65 ± 1.11 n.s.
 Midbrain - 0.26 ± 0.20 n/a - 0.46 ± 0.11 n/a 3.34 ± 1.01 3.40 ± 1.17 n.s.
 Cerebellum - - - - - - 0.52 ± 0.16 0.49 ± 0.44 n.s.
  1. Regional uptake and binding potential of [11C]AZ10419369 in the different brain regions in mice, rats, and guinea pigs during baseline and CsA pretreatment conditions (each value represents mean ± SD). n/a, not applicable; n.s., not significant.