EJNMMI Research

Table 1 The percentage of intact parent compounds in blood plasma in non-human primates

From: Strategy to develop a MAO-A-resistant 5-hydroxy-l-[β-¹¹C]tryptophan isotopologue based on deuterium kinetic isotope effects

	Individual 1				Individual 2
	Baseline		MAO-A inhibited		Baseline		MAO-A inhibited
Time (min)	[¹¹C]HTP	[¹¹C]DHTP	[¹¹C]HTP	[¹¹C]DHTP	[¹¹C]HTP	[¹¹C]DHTP	[¹¹C]HTP	[¹¹C]DHTP
5	89.1	89.1	95.1	95.2	92.0	90.6	95.0	96.2
30	65.0	66.7	73.3	72.6	70.1	68.9	77.0	80.6
60	50.0	53.1	54.3	58.8	56.0	52.3	63.2	65.2

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