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Table 1 The percentage of intact parent compounds in blood plasma in non-human primates

From: Strategy to develop a MAO-A-resistant 5-hydroxy-l-[β-11C]tryptophan isotopologue based on deuterium kinetic isotope effects

  Individual 1 Individual 2
Baseline MAO-A inhibited Baseline MAO-A inhibited
Time (min) [11C]HTP [11C]DHTP [11C]HTP [11C]DHTP [11C]HTP [11C]DHTP [11C]HTP [11C]DHTP
5 89.1 89.1 95.1 95.2 92.0 90.6 95.0 96.2
30 65.0 66.7 73.3 72.6 70.1 68.9 77.0 80.6
60 50.0 53.1 54.3 58.8 56.0 52.3 63.2 65.2