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EJNMMI Research

Table 1 Mean absolute urinary RBP4 and creatinine concentrations and RBP4/creatinine concentration ratios

From: Evaluation of retinol binding protein 4 and carbamoylated haemoglobin as potential renal toxicity biomarkers in adult mice treated with 177Lu-octreotate

  

RBP4 (ng/mL)

Creatinine (mg/dL)

RBP4/creatinine (ng/mg)

Treatment group

Days after therapy

   

Non-treated

Study start

2.5 (0.2)

47 (5)

5.5 (0.7)

14

2.6 (0.3)b

53 (6)

5.1 (0.7)

30

3.5 (0.2)

50 (6)

7.5 (0.8)

60

2.9 (0.3)b

46 (4)

6.6 (0.8)

90

9.6 (2.1)

51 (5)

19 (5)

60 MBq

Study start

3.4 (0.3)

59 (6)

5.9 (0.6)

14

4.2 (0.8)

60 (7)

7.1 (1.2)

30

5.2 (0.5)

62 (7)

8.9 (1.2)

60

17 (8)

68 (9)

31 (17)

90

57 (28)

61 (11)

150 (93)

120 MBq

Study start t

3.5 (0.3)b

53 (4)

7 (1)

14

5.6 (0.9)

48 (6)

12 (2)

30

38 (20)a

43 (5)

94 (49)

60

97 (17)a

22 (4)

480 (73)

90

120 (31)a

41 (4)

350 (72)

  1. Mean absolute urinary RBP4 and creatinine concentrations and RBP4/creatinine concentration ratios at each time-point before and after therapy for non-treated mice or mice treated with 60 or 120 MBq 177Lu-octreotate. Values are given as mean (SEM).
  2. aRBP4 concentration too high to permit exact quantification.
  3. bRBP4 concentration too low to permit exact quantification.
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