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Table 1 Mean absolute urinary RBP4 and creatinine concentrations and RBP4/creatinine concentration ratios

From: Evaluation of retinol binding protein 4 and carbamoylated haemoglobin as potential renal toxicity biomarkers in adult mice treated with 177Lu-octreotate

   RBP4 (ng/mL) Creatinine (mg/dL) RBP4/creatinine (ng/mg)
Treatment group Days after therapy    
Non-treated Study start 2.5 (0.2) 47 (5) 5.5 (0.7)
14 2.6 (0.3)b 53 (6) 5.1 (0.7)
30 3.5 (0.2) 50 (6) 7.5 (0.8)
60 2.9 (0.3)b 46 (4) 6.6 (0.8)
90 9.6 (2.1) 51 (5) 19 (5)
60 MBq Study start 3.4 (0.3) 59 (6) 5.9 (0.6)
14 4.2 (0.8) 60 (7) 7.1 (1.2)
30 5.2 (0.5) 62 (7) 8.9 (1.2)
60 17 (8) 68 (9) 31 (17)
90 57 (28) 61 (11) 150 (93)
120 MBq Study start t 3.5 (0.3)b 53 (4) 7 (1)
14 5.6 (0.9) 48 (6) 12 (2)
30 38 (20)a 43 (5) 94 (49)
60 97 (17)a 22 (4) 480 (73)
90 120 (31)a 41 (4) 350 (72)
  1. Mean absolute urinary RBP4 and creatinine concentrations and RBP4/creatinine concentration ratios at each time-point before and after therapy for non-treated mice or mice treated with 60 or 120 MBq 177Lu-octreotate. Values are given as mean (SEM).
  2. aRBP4 concentration too high to permit exact quantification.
  3. bRBP4 concentration too low to permit exact quantification.