Potential of 99mTc-MIBI SPECT imaging for evaluating non-alcoholic steatohepatitis induced by methionine-choline-deficient diet in mice

EJNMMI Research

Table 1 Plasma parameters in mice fed control and MCD diet for 2 and 4 weeks

Plasma parameter	Control	MCD 2 weeks	MCD 4 weeks
TC (mg/dL)	90.9 ± 2.55	57.7 ± 1.67**	32.9 ± 2.84**
TG (mg/dL)	110 ± 18.4	9.80 ± 1.77**	14.7 ± 1.81**
AST (IU/L)	63.8 ± 21.3	312 ± 84.5**	324 ± 65.8**
ALT (IU/L)	26.7 ± 8.02	191 ± 41.7**	239 ± 31.4**
HDLC (mg/dL)	50.9 ± 1.72	30.8 ± 1.58**	14.4 ± 1.63**

Data are expressed as mean ± SEM of five to seven experiments for each group. Statistical differences were assessed using Dunnett's test. TC, total cholesterol; TG, triglyceride; AST, aspartate transaminase; ALT, alanine aminotransferase; HDLC, high-density lipoprotein cholesterol. *p <0.05, **p <0.01 compared to the control mice.