Table 1 Biodistribution of 177 Lu-DOTA-chCE7 and 177 Lu-DOTA-control IgG 72 h post RIC injection in nude mice bearing subcutaneous IGROV1 tumours (±PTX)
From: Paclitaxel improved anti-L1CAM lutetium-177 radioimmunotherapy in an ovarian cancer xenograft model
Organs | 177Lu-DOTA-chCE7 | 177Lu-DOTA-chCE7 + PTX | 177Lu-DOTA-control IgG | 177Lu-DOTA-control IgG + PTX |
|---|---|---|---|---|
Blood | 8.9 ± 2.8 | 6.9 ± 3.5 | 17.12 ± 3.6 | 13.3 ± 8.5 |
Heart | 3.9 ± 0.8 | 3.3 ± 1.4 | 5.7 ± 2.9 | 3.9 ± 1.7 |
Spleen | 7.0 ± 2.3 | 5.7 ± 1.0 | 5.0 ± 2.8 | 10.2 ± 6.1 |
Kidney | 2.8 ± 0.3 | 2.4 ± 0.6 | 5.4 ± 1.9 | 4.6 ± 1.8 |
Stomach | 0.4 ± 0.2 | 0.4 ± 0.1 | 0.8 ± 0.8 | 1.0 ± 0.4 |
Intestine | 0.8 ± 0.2 | 0.7 ± 0.3 | 1.1 ± 0.3 | 0.4 ± 0.5 |
Liver | 5.3 ± 1.8 | 5.7 ± 0.3 | 5.7 ± 2.5 | 6.7 ± 1.2 |
Muscle | 0.9 ± 0.2 | 0.8 ± 0.2 | 1.1 ± 0.3 | 1.4 ± 0.6 |
Bone | 1.5 ± 0.2 | 1.1 ± 0.5 | 1.9 ± 0.6 | 2.6 ± 0.5 |
Tumour | 49.6 ± 11.9 | 45.3 ± 8.6 | 7.2 ± 2.3 | 9.1 ± 3.1 |