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EJNMMI Research
Figure 2 | EJNMMI Research

Figure 2

From: Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

Figure 2

Concentration dependence of f tb for a hypothetical functioning PET tracer (solid line, Eq.2). Blue and red areas represent the proportions of target-bound tracer and non-specific tracer in brain tissue, respectively. At low concentrations (Cu,brainISF < < Kd), ftb is at a plateau maximum value, which is high for functioning tracers and low for non-functioning tracers. At excessive concentrations (Cu,brainISF > > Kd), the specific binding is saturated and ftb negligible also for a good tracer.

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