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Table 2 Advantages and drawbacks of SUV methods with different VOI metrics used in the current study[5]-[8],[11]-[15],[21],[22]

From: The effect of volume of interest definition on quantification of lymph node immune response to a monkeypox virus infection assessed by 18F-FDG-PET

SUV metrics Current use in clinical settings Major drawbacks or advantages References Statistically significant effects in current study
SUVmean + • PVE at the edges of target region [5],[6],[11]-[14],[21] No
• Time consuming to outline target region
• Inclusion of nontarget tissue
SUVmax + • Susceptible to noise [8],[21],[22] No
• Random voxel location
• Independent of observer
• Easy to apply
SUVthreshold + • Inclusion of nontarget tissue [7],[14],[15] No
• Less sensitive to noise
• Easy to apply
• More reproducible than SUVmean
SUVfixed volume (placement adjusted in current study) + • Less sensitive to noise than SUVmax [7],[8] Yes
• Limits PVE at edges of target region
• Relatively similar location of voxels between scans and between animals
mSUVthreshold - • Less sensitive to noise than SUVmax   Yes
• Relatively easy to apply
• Limits PVE at edges of target region