The effect of volume of interest definition on quantification of lymph node immune response to a monkeypox virus infection assessed by 18F-FDG-PET

EJNMMI Research

Table 2 Advantages and drawbacks of SUV methods with different VOI metrics used in the current study[5]-[8],[11]-[15],[21],[22]

SUV metrics	Current use in clinical settings	Major drawbacks or advantages	References	Statistically significant effects in current study
SUV_mean	+	• PVE at the edges of target region	[5],[6],[11]-[14],[21]	No
		• Time consuming to outline target region
		• Inclusion of nontarget tissue
SUV_max	+	• Susceptible to noise	[8],[21],[22]	No
		• Random voxel location
		• Independent of observer
		• Easy to apply
SUV_threshold	+	• Inclusion of nontarget tissue	[7],[14],[15]	No
		• Less sensitive to noise
		• Easy to apply
		• More reproducible than SUV_mean
SUV_{fixed volume} (placement adjusted in current study)	+	• Less sensitive to noise than SUV_max	[7],[8]	Yes
		• Limits PVE at edges of target region
		• Relatively similar location of voxels between scans and between animals
mSUV_threshold	-	• Less sensitive to noise than SUV_max		Yes
		• Relatively easy to apply
		• Limits PVE at edges of target region