Figure 3

Schematic overview of tissue samples and radiological methods. (A, C) Pt 1. (B, D) Pt 2. (A) and (C) show the same tissue slice, with radiography in (A) and a photo scan in (C). The small region of (A) and (C), limited by the dotted red line, is normal liver parenchyma with no visual signs of tumour involvement, as opposed to the larger tissue region on the other side of the line. The images to the left in (B) and (D) show autoradiography and biopsy punching of normal liver tissue. The images to the right in (B) and (D) show likewise for tumour and normal liver parenchyma without tumour involvement but adjacent to the tumour. The dotted red line in (B) and (D) limits the smaller tumour tissue region from the adjacent normal liver parenchyma without visual signs of tumour involvement. (D) shows how several small tissue biopsies of different sizes have been punched out, from the tissue slices being examined with autoradiography in (B), to measure their activity concentration. For Pt 1, samples were also punched out from the slice shown in (C) but after photography.