Table 1 Kinetic parameters of the blood-brain partitioning of [ ¹⁸ F ]NS14490 in the brain and brain vasculature

Frontal cortex

0.161 (0.055)

0.046 (0.003)

3.78 (1.01)

0.45

0.163 (0.029)

0.059 (0.003)*

2.82 (0.62)

Temporal cortex

0.145 (0.034)

0.040 (0.003)

3.98 (1.02)

0.53

0.145 (0.028)

0.049 (0.001)**

3.04 (0.69)

Parietal cortex

0.149 (0.037)

0.044 (0.001)

3.63 (0.86)

0.40

0.155 (0.034)

0.056 (0.004)*

2.81 (0.61)

Occipital cortex

0.171 (0.064)

0.051 (0.008)

3.59 (0.84)

0.40

0.164 (0.045)

0.062 (0.005)***

2.70 (0.59)

Basal forebrain

0.163 (0.035)

0.048 (0.006)

3.75 (0.74)

0.44

0.164 (0.040)

0.055 (0.002) n.s.

3.04 (0.72)

Hippocampus

0.146 (0.044)

0.045 (0.005)

3.50 (0.68)

0.35

0.154 (0.035)

0.062 (0.010)***

2.60 (0.61)

Striatum

0.137 (0.029)

0.043 (0.004)

3.48 (0.80)

0.34

0.149 (0.038)

0.055 (0.001)**

2.76 (0.71)

Thalamus

0.160 (0.032)

0.049 (0.003)

3.54 (0.69)

0.35

0.177 (0.039)

0.065 (0.001)*

2.78 (0.68)

Midbrain tegmentum

0.161 (0.026)

0.053 (0.007)

3.47 (0.99)

0.33

0.159 (0.034)

0.062 (0.004) n.s.

2.59 (0.61)

Colliculi

0.162 (0.035)

0.059 (0.003)

3.05 (0.71)

0.17

0.178 (0.042)

0.071 (0.006)**

2.53 (0.50)

Pons

0.205 (0.090)

0.066 (0.010)

3.33 (0.85)

0.28

0.201 (0.034)

0.077 (0.011) n.s.

2.72 (0.84)

Cerebellum

0.186 (0.078)

0.061 (0.005)

3.15 (0.96)

0.21

0.193 (0.064)

0.070 (0.003)***

2.80 (0.96)

Full brain

0.170 (0.054)

0.050 (0.004)

3.56 (0.85)

0.37

0.166 (0.032)

0.059 (0.001)**

2.78 (0.66)

Carotid artery

0.406 (0.194)

0.059 (0.015)

6.71 (1.37)

0.18

0.367 (0.095)

0.064 (0.002) n.s.

5.71 (1.37)

Circle of Willis

0.285 (0.136)

0.050 (0.012)

5.37 (1.35)

0.11

0.254 (0.132)

0.051 (0.021) n.s.

4.83 (0.86)