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Table 1 Kinetic parameters of the blood-brain partitioning of [ 18 F ]NS14490 in the brain and brain vasculature

From: Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490

  Control (n = 4)a Blocked (n = 3)a
  K 1 k2 VT BPND K 1 k2 VT
Frontal cortex 0.161 (0.055) 0.046 (0.003) 3.78 (1.01) 0.45 0.163 (0.029) 0.059 (0.003)* 2.82 (0.62)
Temporal cortex 0.145 (0.034) 0.040 (0.003) 3.98 (1.02) 0.53 0.145 (0.028) 0.049 (0.001)** 3.04 (0.69)
Parietal cortex 0.149 (0.037) 0.044 (0.001) 3.63 (0.86) 0.40 0.155 (0.034) 0.056 (0.004)* 2.81 (0.61)
Occipital cortex 0.171 (0.064) 0.051 (0.008) 3.59 (0.84) 0.40 0.164 (0.045) 0.062 (0.005)*** 2.70 (0.59)
Basal forebrain 0.163 (0.035) 0.048 (0.006) 3.75 (0.74) 0.44 0.164 (0.040) 0.055 (0.002) n.s. 3.04 (0.72)
Hippocampus 0.146 (0.044) 0.045 (0.005) 3.50 (0.68) 0.35 0.154 (0.035) 0.062 (0.010)*** 2.60 (0.61)
Striatum 0.137 (0.029) 0.043 (0.004) 3.48 (0.80) 0.34 0.149 (0.038) 0.055 (0.001)** 2.76 (0.71)
Thalamus 0.160 (0.032) 0.049 (0.003) 3.54 (0.69) 0.35 0.177 (0.039) 0.065 (0.001)* 2.78 (0.68)
Midbrain tegmentum 0.161 (0.026) 0.053 (0.007) 3.47 (0.99) 0.33 0.159 (0.034) 0.062 (0.004) n.s. 2.59 (0.61)
Colliculi 0.162 (0.035) 0.059 (0.003) 3.05 (0.71) 0.17 0.178 (0.042) 0.071 (0.006)** 2.53 (0.50)
Pons 0.205 (0.090) 0.066 (0.010) 3.33 (0.85) 0.28 0.201 (0.034) 0.077 (0.011) n.s. 2.72 (0.84)
Cerebellum 0.186 (0.078) 0.061 (0.005) 3.15 (0.96) 0.21 0.193 (0.064) 0.070 (0.003)*** 2.80 (0.96)
Full brain 0.170 (0.054) 0.050 (0.004) 3.56 (0.85) 0.37 0.166 (0.032) 0.059 (0.001)** 2.78 (0.66)
Carotid artery 0.406 (0.194) 0.059 (0.015) 6.71 (1.37) 0.18 0.367 (0.095) 0.064 (0.002) n.s. 5.71 (1.37)
Circle of Willis 0.285 (0.136) 0.050 (0.012) 5.37 (1.35) 0.11 0.254 (0.132) 0.051 (0.021) n.s. 4.83 (0.86)
  1. Data are obtained from a one-tissue compartment model. Values are means ± S.D.; n.s., not significant. aThe unidirectional blood-brain clearance (K1; mL g−1 min−1), the apparent washout rate constant from the brain (k2″; min−1) and the total distribution volume (VT″; mL g−1) were calculated with plasma volume fixed at 0.025 mL g−1. In the unblocked condition, we calculated the binding potential BPND relative to VT″ in the blocked condition. Significant difference between k2″ in the two groups: *p < 0.001, **p < 0.005, ***p < 0.01.