18 F-FDG PET standard uptake values of the normal pons in children: establishing a reference value for diffuse intrinsic pontine glioma

EJNMMI Research

Table 1 Baseline and PET characteristics of controls and patients with DIPG

	Controls	DIPG
Number of subjects	36^a	6
Male	21	2
Female	15	4
Median age (years)	12 (±4)	6 (±5)
0 to 5	0	2
6 to 10	15	3
11 to 15	14	0
16 to 20	5	1
20 to 25	2	0
Anti-epileptic drugs
Valproic acid	3	0
Clobazam	4	0
Carbamazepine	12	0
Levetiracetam	6	0
Lamotrigine	9	0
Other	3	0
Histology
Anaplastic astrocytoma		2 (biopsy)
Glioblastoma multiforme		1 (autopsy)
DIPG histology unknown		3
PET characteristics
Mean ¹⁸ F-FDG dose (MBq)	187 (±11)	170 (±29)
Mean scan duration (min)	15 (±0)	16 (±2)
15 min	35	5
20 min	1	1
¹⁸ F-FDG uptake interval time
Mean (min)	48 (±16)	50 (±27)
PET reconstruction parameters
Method	OSEM	OSEM
Matrix 256	34	6
Matrix 128	2	0

OSEM, ordered subset expectation maximization. ^aThe controls consisted of 6 subjects with temporal lobe, 1 with parietal lobe, and 2 with frontal lobe epileptogenic foci; 5 with hypometabolism of the hippocampus; 5 with focal cortical dysplasia; 3 with mesial temporal sclerosis; and 14 without structural or ¹⁸F-FDG PET epileptogenic foci.