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Table 3 CT-perfusion parameters by UICC stage (seventh edition) and PET positivity of lymph nodes

From: Multiparametric PET/CT-perfusion does not add significant additional information for initial staging in lung cancer compared with standard PET/CT

CT-perfusion parameters UICC stage PET-positive lymph nodes
All tumors ( n = 46) I ( n = 6) II ( n = 10) III (n = 12) IV ( n = 18) p No (n = 17) Yes ( n = 29) p
 Blood flow (mL/100 mL min-1), mean ± SD 30.0 ± 17.8 42.0 ± 44.4 37.8 ± 13.0 32.2 ± 12.9 0.61 45.7 ± 33.6 29.5 ± 12.0 0.02
 Blood volume (mL/100 mL), mean ± SD 7.3 ± 6.1 7.5 ± 4.4 9.7 ± 9.2 8.4 ± 5.4 0.82 11.1 ± 8.4 6.8 ± 4.1 0.02
 Mean transit time (s), mean ± SD 12.8 ± 5.8 13.8 ± 4.2 13.7 ± 5.0 15.2 ± 4.1 0.79 12.9 ± 4.6 14.9 ± 4.4 0.09
NSCLC ( n  = 41) I ( n  = 6) II ( n  = 9) III ( n  = 11) IV ( n  = 15) p No ( n  = 17) Yes ( n  = 24) p
 Blood flow (mL/100 mL min-1), mean ± SD 30.0 ± 17.8 43.0 ± 47.0 37.8 ± 13.0 32.2 ± 12.9 0.70 45.7 ± 33.6 28.3 ± 11.5 0.01
 Blood volume (mL/100 mL), mean ± SD 7.3 ± 6.1 7.8 ± 4.5 10.0 ± 9.6 8.0 ± 5.3 0.84 11.1 ± 8.4 6.5 ± 3.9 0.01
 Mean transit time (s), mean ± SD 12.8 ± 5.8 13.5 ± 4.3 14.3 ± 4.6 15.6 ± 4.3 0.72 12.9 ± 4.6 15.4 ± 4.3 0.04
  1. CT, computed tomography; NSCLC, non-small cell lung carcinoma; PET, positron emission tomography; SD, standard deviation; UICC, Union for International Cancer Control.