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Table 3 CT-perfusion parameters by UICC stage (seventh edition) and PET positivity of lymph nodes

From: Multiparametric PET/CT-perfusion does not add significant additional information for initial staging in lung cancer compared with standard PET/CT

CT-perfusion parameters

UICC stage

PET-positive lymph nodes

All tumors ( n = 46)

I ( n = 6)

II ( n = 10)

III (n = 12)

IV ( n = 18)

p

No (n = 17)

Yes ( n = 29)

p

 Blood flow (mL/100 mL min-1), mean ± SD

30.0 ± 17.8

42.0 ± 44.4

37.8 ± 13.0

32.2 ± 12.9

0.61

45.7 ± 33.6

29.5 ± 12.0

0.02

 Blood volume (mL/100 mL), mean ± SD

7.3 ± 6.1

7.5 ± 4.4

9.7 ± 9.2

8.4 ± 5.4

0.82

11.1 ± 8.4

6.8 ± 4.1

0.02

 Mean transit time (s), mean ± SD

12.8 ± 5.8

13.8 ± 4.2

13.7 ± 5.0

15.2 ± 4.1

0.79

12.9 ± 4.6

14.9 ± 4.4

0.09

NSCLC ( n  = 41)

I ( n  = 6)

II ( n  = 9)

III ( n  = 11)

IV ( n  = 15)

p

No ( n  = 17)

Yes ( n  = 24)

p

 Blood flow (mL/100 mL min-1), mean ± SD

30.0 ± 17.8

43.0 ± 47.0

37.8 ± 13.0

32.2 ± 12.9

0.70

45.7 ± 33.6

28.3 ± 11.5

0.01

 Blood volume (mL/100 mL), mean ± SD

7.3 ± 6.1

7.8 ± 4.5

10.0 ± 9.6

8.0 ± 5.3

0.84

11.1 ± 8.4

6.5 ± 3.9

0.01

 Mean transit time (s), mean ± SD

12.8 ± 5.8

13.5 ± 4.3

14.3 ± 4.6

15.6 ± 4.3

0.72

12.9 ± 4.6

15.4 ± 4.3

0.04

  1. CT, computed tomography; NSCLC, non-small cell lung carcinoma; PET, positron emission tomography; SD, standard deviation; UICC, Union for International Cancer Control.