Table 2 Diagnostic performance of each type of MBI acquisition
From: Half-time Tc-99m sestamibi imaging with a direct conversion molecular breast imaging system
Reader 1 | Reader 2 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
10 min-per-view | 5 min-per-view | 5 min-per-view with WBR | p value* | 10 min-per-view | 5 min-per-view | 5 min-per-view with WBR | p value* | |||||||||||
10 min vs. 5 min | 10 min vs. 5 min WBR | 5 min vs. 5 min WBR | 10 min vs. 5 min | 10 min vs. 5 min WBR | 5 min vs. 5 min WBR | |||||||||||||
No. of breasts | 95% CIs | No. of breasts | 95% CIs | No. of breasts | 95% CIs | No. of breasts | 95% CIs | No. of breasts | 95% CIs | No. of breasts | 95% CIs | |||||||
Detection of both malignant and benign lesions | ||||||||||||||||||
Sensitivity for all lesions*** | 40/49 (82) | 68.6, 90.0 | 33/49 (67) | 53.4, 78.8 | 32/49 (65) | 51.3, 77.1 | 0.04 | 0.02 | 1.00 | 43/49 (88) | 75.8, 94.3 | 36/49 (74) | 59.7, 83.8 | 37/49 (76) | 61.9, 85.4 | 0.02 | 0.03 | 1.00 |
Lesions ≤10 mm | 13/17 (77) | 52.7, 90.4 | 9/17 (53) | 31.0, 73.8 | 7/17 (41) | 21.6, 64.0 | 0.13 | 0.03 | 0.50 | 12/17 (71) | 46.9, 86.7 | 8/17 (47) | 26.2, 69.0 | 9/17 (53) | 31.0, 73.8 | 0.13 | 0.25 | 1.00 |
Lesions >10 mm | 27/32 (84) | 68.2, 93.1 | 24/32 (75) | 57.9, 86.7 | 25/32 (78) | 61.2, 89.0 | 0.38 | 0.63 | 1.00 | 31/32 (97) | 84.3, 99.4 | 28/32 (88) | 71.9, 95.0 | 28/32 (88) | 71.9, 95.0 | 0.25 | 0.25 | 1.00 |
p value ≤ 10 mm vs. > 10 mm** | 0.70 | 0.20 | 0.01 | 0.02 | 0.01 | 0.01 | ||||||||||||
Mild intensity lesions | 11/18 (61) | 38.6, 79.7 | 5/18 (28) | 12.5, 50.9 | 4/18 (22) | 9.0, 45.2 | 0.03 | 0.02 | 1.00 | 12/18 (67) | 43.7, 83.7 | 7/18 (39) | 20.3, 61.4 | 7/18 (39) | 20.3, 61.4 | 0.06 | 0.06 | 1.00 |
Moderate/Marked intensity lesions | 29/31 (94) | 79.3, 98.2 | 28/31 (90) | 75.1, 96.7 | 28/31 (90) | 75.1, 96.7 | 1.00 | 1.00 | NDP | 31/31 (100) | 89.0, 100 | 29/31 (94) | 79.3, 98.2 | 30/31 (97) | 83.8, 99.4 | NDP | NDP | 1.00 |
p value, mild vs. moderate/high intensity** | 0.01 | <0.001 | <0.001 | 0.001 | <0.001 | <0.001 | ||||||||||||
Low image count density | 7/8 (88) | 52.9, 97.8 | 7/8 (88) | 52.9, 97.8 | 6/8 (75) | 40.9, 92.9 | NDP | 1.00 | 1.00 | 7/8 (88) | 52.9, 97.8 | 6/8 (75) | 40.9, 92.9 | 7/8 (88) | 52.9, 97.8 | 1.00 | NDP | 1.00 |
Intermediate/high image count density | 33/41 (81) | 66.0, 89.8 | 26/41 (63) | 48.1, 76.4 | 26/41 (63) | 48.1, 76.4 | 0.04 | 0.04 | 1.00 | 36/41 (88) | 74.5, 94.7 | 30/41 (73) | 58.1, 84.3 | 30/41 (73) | 58.1, 84.3 | 0.03 | 0.03 | 1.00 |
p value, low vs. intermediate/high image count density** | 1.00 | 0.25 | 0.70 | 1.00 | 1.00 | 0.66 | ||||||||||||
Specificity | 115/115 (100) | 96.8, 100.0 | 114/115 (99) | 95.2, 99.8 | 115/115 (100) | 96.8, 100.0 | 1.00 | NDP | 1.00 | 115/115 (100) | 96.8, 100.0 | 114/115 (99) | 95.2, 99.8 | 115/115 (100) | 96.8, 100.0 | 1.00 | NDP | 1.00 |
AUC | 95% CIs | AUC | 95% CIs | AUC | 95% CIs | AUC | 95% CIs | AUC | 95% CIs | AUC | 95% CIs | |||||||
ROC analysis | 99.4 | 98.8, 99.9 | 91.9 | 86.5, 97.4 | 93.8 | 89.1, 98.4 | 0.01 | 0.02 | 0.39 | 99.8 | 99.6, 100.0 | 93.4 | 88.5, 98.2 | 96.0 | 92.2, 99.8 | 0.01 | 0.04 | 0.23 |
Detection of malignant lesions only | ||||||||||||||||||
Sensitivity for malignant lesions | 29/33 (88) | 72.7, 95.2 | 26/33 (79) | 62.2, 89.3 | 27/33 (82) | 65.6, 91.4 | 0.25 | 0.50 | 1.00 | 31/33 (94) | 80.4, 98.3 | 29/33 (88) | 72.7, 95.2 | 28/33 (85) | 69.1, 93.3 | 0.50 | 0.25 | 1.00 |
Cancers ≤10 mm | 6/8 (75) | 40.9, 92.9 | 5/8 (63) | 30.6, 86.3 | 5/8 (63) | 30.6, 86.3 | 1.00 | 1.00 | NDP | 6/8 (75) | 40.9, 92.9 | 5/8 (63) | 30.6, 86.3 | 5/8 (63) | 30.6, 86.3 | 1.00 | 1.00 | NDP |
Cancers >10 mm | 23/25 (92) | 75.0, 97.8 | 21/25 (84) | 65.3, 93.6 | 22/25 (88) | 70.0, 95.8 | 0.50 | 1.00 | 1.00 | 25/25 (100) | 86.7, 100 | 24/25 (96) | 80.5, 99.3 | 23/25 (92) | 75.0, 97.8 | 1.00 | 1.00 | 1.00 |
p value ≤ 10 mm vs. > 10 mm** | 0.24 | 0.32 | 0.14 | 0.053 | 0.036 | 0.080 | ||||||||||||
Mild intensity cancers | 5/9 (56) | 26.7, 81.1 | 3/9 (33) | 12.1, 64.6 | 4/9 (44) | 18.9, 73.3 | 0.50 | 1.00 | 1.00 | 7/9 (78) | 45.3, 93.7 | 6/9 (67) | 35.4, 87.9 | 4/9 (44) | 18.9, 73.3 | 1.00 | 0.25 | 0.50 |
Moderate/marked intensity cancers | 24/24 (100) | 86.2, 100 | 23/24 (96) | 79.8, 99.3 | 23/24 (96) | 79.8, 99.3 | 1.00 | 1.00 | NDP | 24/24 (100) | 86.2, 100 | 23/24 (96) | 79.8, 99.3 | 24/24 (100) | 86.2, 100 | 1.00 | 1.00 | 1.00 |
p value, mild vs. moderate/high intensity** | 0.003 | < 0.001 | 0.003 | 0.068 | 0.052 | < 0.001 | ||||||||||||
Low image count density | 6/7 (86) | 48.7, 97.4 | 6/7 (86) | 48.7, 97.4 | 6/7 (86) | 48.7, 97.4 | NDP | NDP | NDP | 6/7 (86) | 48.7, 97.4 | 6/7 (86) | 48.7, 97.4 | 6/7 (86) | 48.7, 97.4 | NDP | NDP | NDP |
Intermediate/high image count density | 23/26 (89) | 71.0, 96.0 | 20/26 (77) | 58.0, 89.0 | 21/26 (81) | 62.1, 91.5 | 0.25 | 0.50 | 1.00 | 25/26 (96) | 81.1, 99.3 | 23/26 (89) | 71.0, 96.0 | 22/26 (85) | 66.5, 93.8 | 0.50 | 0.25 | 1.0 |
p value, low vs. intermediate/high image count density** | 1.00 | 1.00 | 1.00 | 0.38 | 1.00 | 1.00 | ||||||||||||
Specificity | 120/131 (92) | 85.6, 95.2 | 123/131 (94) | 88.4, 96.9 | 126/131 (96) | 91.4, 98.4 | 0.45 | 0.07 | 0.25 | 119/131 (91) | 84.7, 94.7 | 123/131 (94) | 88.4, 96.9 | 122/131 (93) | 87.5, 96.3 | 0.22 | 0.25 | 1.00 |
AUC | 95% CIs | AUC | 95% CIs | AUC | 95% CIs | AUC | 95% CIs | AUC | 95% CIs | AUC | 95% CIs | |||||||
ROC analysis | 96.0 | 93.6, 98.3 | 95.0 | 90.9, 99.1 | 96.9 | 94.3, 99.0 | 0.56 | 0.45 | 0.21 | 96.1 | 93.9, 98.3 | 94.9 | 90.8, 98.9 | 94.7 | 90.6, 98.7 | 0.47 | 0.38 | 0.93 |