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Table 3 Biodistribution of 123 I-CMICE-013 in healthy Sprague–Dawley rats

From: Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats

Organ %ID/organ (mean ± SD)
2 min 23 min 43 min 62 min 82 min 102 min 24 h
Thyroid 0.47 ± 0.20 0.48 ± 0.19 0.48 ± 0.17 0.48 ± 0.17 0.49 ± 0.15 0.49 ± 0.14 0.69 ± 0.23
Stomach 6.70 ± 2.25 7.84 ± 1.68 8.71 ± 1.24 10.10 ± 0.98 11.60 ± 1.10 13.09 ± 1.58 1.30 ± 0.34
Liver 17.96 ± 4.46 13.84 ± 4.63 11.39 ± 4.21 9.61 ± 3.59 8.30 ± 3.19 7.39 ± 2.95 n/a
Heart 4.18 ± 0.99 3.69 ± 0.77 3.24 ± 0.70 2.81 ± 0.62 2.43 ± 0.56 2.16 ± 0.48 n/a
Bladder 0.15 ± 0.19 0.42 ± 0.40 0.52 ± 0.49 0.56 ± 0.52 0.61 ± 0.56 0.64 ± 0.57 0.16 ± 0.07
Intestine 4.69 ± 2.78 5.81 ± 2.91 7.63 ± 3.24 8.28 ± 3.18 8.06 ± 3.07 7.91 ± 3.02 0.58 ± 0.33
Sal. gland 2.97 ± 1.12 3.04 ± 1.16 3.06 ± 1.16 3.05 ± 1.16 3.00 ± 1.13 2.95 ± 1.11 n/a
  1. Fourteen animals were divided into two groups. Group no. 1 (n = 6) was used in 0- to 2-h imaging and group no. 2 (n = 8) was used in 24-h imaging. At 24 h post-injection, no activity was observed in the microSPECT images of the liver, heart, and salivary gland.