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Table 2 Metrics for agreement of simultaneously estimated and blood-sampled input functions with simulation of spillover

From: Estimation of input functions from dynamic [18F]FLT PET studies of the head and neck with correction for partial volume effects

  Init BSIF Number of samples Init PET Number of samples
  0 1 2 3 0 1 2 3
RMS norm 3.9 2.0 (0.7) 1.1 (0.5) 1.2 2.9 2.0 (0.3) 1.1 (0.4) 1.1
Peak AUC (%) 40 27 (8) 16 (7) 11 41 25 (9) 17 (9) 13
Tail AUC (%) 87 34 (15) 19 (11) 12 108 32 (9) 21 (15) 15
  1. Median (median interquartile range) of RMS norm values and errors of the area under the peak and tail of the estimated input function, as the moduli of the percentages of the areas under the blood-sampled input function (calculated with simulation of spillover). Samples were taken at late times (one sample only), combinations of intermediate and late times (two samples), and an early, intermediate and late time (three samples).