Compound | Time (min) | Brain | Liver | Spleen | Kidneys | Femur | Lungs | Heart | Blood | Pancreas | Ovaries | Tumour |
---|---|---|---|---|---|---|---|---|---|---|---|---|
18F-SIG343 | 15 | 9.6 ± 0.2*** | 16.0 ± 0.9** | 14.6 ± 1.2 | 26.1 ± 0.6 | 4.5 ± 0.4 | 30.3 ± 1.2*** | 5.5 ± 0.4 | 0.9 ± 0.1 | 42.9 ± 2.8* | 10.8 ± 1.8 | 3.1 ± 0.5 |
30 | 8.8 ± 0.6*** | 21.9 ± 0.8*** | 15.2 ± 1.1* | 19.8 ± 0.9*** | 4.3 ± 0.2 | 17.4 ± 0.7*** | 3.5 ± 0.2** | 0.7 ± 0.04 | 50.2 ± 2.0*** | 14.0 ± 2.2 | 3.0 ± 0.1* | |
60 | 7.1 ± 0.4*** | 15.2 ± 1.1*** | 12.8 ± 0.9*** | 12.0 ± 0.6** | 3.8 ± 0.1 | 9.9 ± 0.3*** | 1.9 ± 0.04** | 0.6 ± 0.1 | 64.4 ± 3.5*** | 13.5 ± 2.2 | 3.5 ± 0.3* | |
120 | 5.2 ± 0.7*** | 19.8 ± 0.9* | 8.5 ± 0.2*** | 7.5 ± 0.4 | 3.2 ± 0.1 | 5.0 ± 0.3 | 1.1 ± 0.1 | 0.4 ± 0.01 | 61.7 ± 3.4*** | 11.5 ± 1.4 | 3.9 ± 0.2 | |
18F-SIG353 | 15 | 4.4 ± 0.2 | 23.5 ± 2.0 | 15.7 ± 1.1 | 23.4 ± 2.0 | 5.3 ± 0.3 | 17.4 ± 0.5 | 4.5 ± 0.2 | 1.2 ± 0.03 | 56.4 ± 4.7 | 10.0 ± 0.9 | 3.8 ± 0.3 |
30 | 2.3 ± 0.1 | 33.0 ± 1.8 | 12.0 ± 0.6 | 13.3 ± 0.8 | 4.7 ± 0.2 | 8.6 ± 0.4 | 2.5 ± 0.1 | 1.0 ± 0.1 | 72.8 ± 2.4 | 11.8 ± 1.5 | 3.8 ± 0.3 | |
60 | 1.3 ± 0.01 | 32.6 ± 1.0 | 7.7 ± 0.4 | 8.7 ± 0.3 | 3.8 ± 0.2 | 6.1 ± 0.1 | 1.7 ± 0.02 | 0.7 ± 0.02 | 94.3 ± 4.2 | 9.6 ± 1.5 | 4.6 ± 0.2 | |
120 | 0.8 ± 0.02 | 24.1 ± 1.4 | 5.5 ± 0.2 | 7.1 ± 0.2 | 3.9 ± 0.1 | 4.7 ± 0.2 | 1.3 ± 0.1 | 0.7 ± 0.03 | 119.2 ± 1.6 | 12.2 ± 3.1 | 4.8 ± 0.4 |