|
Compound
|
Time (min)
|
Brain
|
Liver
|
Spleen
|
Kidneys
|
Femur
|
Lungs
|
Heart
|
Blood
|
Pancreas
|
Ovaries
|
Tumour
|
|---|
|
18F-SIG343
|
15
|
9.6 ± 0.2***
|
16.0 ± 0.9**
|
14.6 ± 1.2
|
26.1 ± 0.6
|
4.5 ± 0.4
|
30.3 ± 1.2***
|
5.5 ± 0.4
|
0.9 ± 0.1
|
42.9 ± 2.8*
|
10.8 ± 1.8
|
3.1 ± 0.5
|
|
30
|
8.8 ± 0.6***
|
21.9 ± 0.8***
|
15.2 ± 1.1*
|
19.8 ± 0.9***
|
4.3 ± 0.2
|
17.4 ± 0.7***
|
3.5 ± 0.2**
|
0.7 ± 0.04
|
50.2 ± 2.0***
|
14.0 ± 2.2
|
3.0 ± 0.1*
|
|
60
|
7.1 ± 0.4***
|
15.2 ± 1.1***
|
12.8 ± 0.9***
|
12.0 ± 0.6**
|
3.8 ± 0.1
|
9.9 ± 0.3***
|
1.9 ± 0.04**
|
0.6 ± 0.1
|
64.4 ± 3.5***
|
13.5 ± 2.2
|
3.5 ± 0.3*
|
|
120
|
5.2 ± 0.7***
|
19.8 ± 0.9*
|
8.5 ± 0.2***
|
7.5 ± 0.4
|
3.2 ± 0.1
|
5.0 ± 0.3
|
1.1 ± 0.1
|
0.4 ± 0.01
|
61.7 ± 3.4***
|
11.5 ± 1.4
|
3.9 ± 0.2
|
|
18F-SIG353
|
15
|
4.4 ± 0.2
|
23.5 ± 2.0
|
15.7 ± 1.1
|
23.4 ± 2.0
|
5.3 ± 0.3
|
17.4 ± 0.5
|
4.5 ± 0.2
|
1.2 ± 0.03
|
56.4 ± 4.7
|
10.0 ± 0.9
|
3.8 ± 0.3
|
|
30
|
2.3 ± 0.1
|
33.0 ± 1.8
|
12.0 ± 0.6
|
13.3 ± 0.8
|
4.7 ± 0.2
|
8.6 ± 0.4
|
2.5 ± 0.1
|
1.0 ± 0.1
|
72.8 ± 2.4
|
11.8 ± 1.5
|
3.8 ± 0.3
|
|
60
|
1.3 ± 0.01
|
32.6 ± 1.0
|
7.7 ± 0.4
|
8.7 ± 0.3
|
3.8 ± 0.2
|
6.1 ± 0.1
|
1.7 ± 0.02
|
0.7 ± 0.02
|
94.3 ± 4.2
|
9.6 ± 1.5
|
4.6 ± 0.2
|
|
120
|
0.8 ± 0.02
|
24.1 ± 1.4
|
5.5 ± 0.2
|
7.1 ± 0.2
|
3.9 ± 0.1
|
4.7 ± 0.2
|
1.3 ± 0.1
|
0.7 ± 0.03
|
119.2 ± 1.6
|
12.2 ± 3.1
|
4.8 ± 0.4
|
- Data are presented as the means of percentage of injected dose per g of tissue (%ID/g ± SEM, n = 5). Comparisons of 18F-SIG343 vs. 18F-SIG353, unpaired two-tailed Student's t test, matched organ and time point. SEM scanning electron microscopy *0.01 < P < 0.05 (significant); **0.001 < P < 0.01 (very significant); ***P < 0.001 (extremely significant).
