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Table 3 Biodistribution of 18 F-SIG343 and 18 F-SIG353 in representative tissues (decay corrected)

From: Synthesis and biological characterisation of 18F-SIG343 and 18F-SIG353, novel and high selectivity σ2 radiotracers, for tumour imaging properties

Compound Time (min) Brain Liver Spleen Kidneys Femur Lungs Heart Blood Pancreas Ovaries Tumour
18F-SIG343 15 9.6 ± 0.2*** 16.0 ± 0.9** 14.6 ± 1.2 26.1 ± 0.6 4.5 ± 0.4 30.3 ± 1.2*** 5.5 ± 0.4 0.9 ± 0.1 42.9 ± 2.8* 10.8 ± 1.8 3.1 ± 0.5
30 8.8 ± 0.6*** 21.9 ± 0.8*** 15.2 ± 1.1* 19.8 ± 0.9*** 4.3 ± 0.2 17.4 ± 0.7*** 3.5 ± 0.2** 0.7 ± 0.04 50.2 ± 2.0*** 14.0 ± 2.2 3.0 ± 0.1*
60 7.1 ± 0.4*** 15.2 ± 1.1*** 12.8 ± 0.9*** 12.0 ± 0.6** 3.8 ± 0.1 9.9 ± 0.3*** 1.9 ± 0.04** 0.6 ± 0.1 64.4 ± 3.5*** 13.5 ± 2.2 3.5 ± 0.3*
120 5.2 ± 0.7*** 19.8 ± 0.9* 8.5 ± 0.2*** 7.5 ± 0.4 3.2 ± 0.1 5.0 ± 0.3 1.1 ± 0.1 0.4 ± 0.01 61.7 ± 3.4*** 11.5 ± 1.4 3.9 ± 0.2
18F-SIG353 15 4.4 ± 0.2 23.5 ± 2.0 15.7 ± 1.1 23.4 ± 2.0 5.3 ± 0.3 17.4 ± 0.5 4.5 ± 0.2 1.2 ± 0.03 56.4 ± 4.7 10.0 ± 0.9 3.8 ± 0.3
30 2.3 ± 0.1 33.0 ± 1.8 12.0 ± 0.6 13.3 ± 0.8 4.7 ± 0.2 8.6 ± 0.4 2.5 ± 0.1 1.0 ± 0.1 72.8 ± 2.4 11.8 ± 1.5 3.8 ± 0.3
60 1.3 ± 0.01 32.6 ± 1.0 7.7 ± 0.4 8.7 ± 0.3 3.8 ± 0.2 6.1 ± 0.1 1.7 ± 0.02 0.7 ± 0.02 94.3 ± 4.2 9.6 ± 1.5 4.6 ± 0.2
120 0.8 ± 0.02 24.1 ± 1.4 5.5 ± 0.2 7.1 ± 0.2 3.9 ± 0.1 4.7 ± 0.2 1.3 ± 0.1 0.7 ± 0.03 119.2 ± 1.6 12.2 ± 3.1 4.8 ± 0.4
  1. Data are presented as the means of percentage of injected dose per g of tissue (%ID/g ± SEM, n = 5). Comparisons of 18F-SIG343 vs. 18F-SIG353, unpaired two-tailed Student's t test, matched organ and time point. SEM scanning electron microscopy *0.01 < P < 0.05 (significant); **0.001 < P < 0.01 (very significant); ***P < 0.001 (extremely significant).