About inflammation and infection: reply to Signore Anne Roivainen, Turku PET Centre, University of Turku and Turku University Hospital 13 February 2013 Anu Autio1, Sirpa Jalkanen2, Anne Roivainen1,3* * Corresponding author Email: email@example.com Author details 1Turku PET Centre, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, Turku 20521, Finland. 2MediCity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, Turku 20520, Finland. 3Turku Center for Disease Modeling, University of Turku, Turku 20520, Finland. Dear Editor, We agree with Dr. Alberto Signore and his letter  nicely defines inflammation and infection, which we did not make clear enough in our review . However, the endothelial molecules guiding the migration of leukocytes to sites of inflammation and infection are practically taken the same as infection always has inflammatory components. Therefore, it is highly unlikely that imaging endothelial molecules one can easily discriminate between infection and inflammation. References 1. Signore A: About inflammation and infection. EJNMMI Res 2013, 3(1):8. 2. Autio A, Jalkanen S, Roivainen A: Nuclear imaging of inflammation: homingassociated molecules as targets. EJNMMI Res 2013, 3(1):1. Competing interests The authors declare that they have no competing interests.