Figure 1

Reference and target tissue TACs in [¹¹ C]PIB PET. (A) Cerebellar (reference tissue) data (open circle) up to 90 min in one AD subject and the fit of 40-min data to the 2P model (solid line). (B) Cerebral cortical (target tissue) data (open circle) in the same subject and the fits of 40-min data to the 3P model with arterial-plasma input (3P + analysis; solid line) or reference tissue input (3P++ analysis; dashed line). The dotted lines in (A) and (B) indicate the extension of the solid line from 40 to 90 min.