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EJNMMI Research

Table 3 Synergism analysis of various schedules of administration of bortezomib { 131 I-MIBG + topotecan}

From: Radiosensitization of noradrenaline transporter-expressing tumour cells by proteasome inhibitors and the role of reactive oxygen species

Effect level

Combination index*

Combination index*

SK-N-BE(2c) cells

UVW/NAT cells

Simultaneous

BZ before

BZ after

Simultaneous

BZ before

BZ after

ED25

1.46

1.42

0.64

1.30

1.71

0.77

ED50

1.54

1.70

0.63

1.44

2.02

0.77

ED75

1.63

2.04

0.63

1.60

2.41

0.79

  1. Asterisk '*’ indicates that the combination index values are means of four experiments. Administration schedules were simultaneous, bortezomib 24 h before {131I-MIBG + topotecan} (BZ before) and bortezomib 24 h after {131I-MIBG + topotecan} (BZ after). Italicised values indicate synergy.
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