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Table 3 Synergism analysis of various schedules of administration of bortezomib { 131 I-MIBG + topotecan}

From: Radiosensitization of noradrenaline transporter-expressing tumour cells by proteasome inhibitors and the role of reactive oxygen species

Effect level Combination index* Combination index*
SK-N-BE(2c) cells UVW/NAT cells
Simultaneous BZ before BZ after Simultaneous BZ before BZ after
ED25 1.46 1.42 0.64 1.30 1.71 0.77
ED50 1.54 1.70 0.63 1.44 2.02 0.77
ED75 1.63 2.04 0.63 1.60 2.41 0.79
  1. Asterisk '*’ indicates that the combination index values are means of four experiments. Administration schedules were simultaneous, bortezomib 24 h before {131I-MIBG + topotecan} (BZ before) and bortezomib 24 h after {131I-MIBG + topotecan} (BZ after). Italicised values indicate synergy.