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Table 2 Ex vivo biodistribution studies of18F-OEG-folate 12 in mice at various time points and18F-click folate

From: 18 F-click labeling and preclinical evaluation of a new 18 F-folate for PET imaging

  30 min p.i. 60 min p.i. 90 min p.i. 60 min p.i. blockade a 18F-click folate 45 min p.i. b
(n = 3) (n = 3) (n = 3) (n = 3) (n = 4)
%ID/g      
 Blood 0.20 ± 0.02 0.18 ± 0.01 0.16 ± 0.02 0.04 ± 0.01 0.13 ± 0.01
 Heart 1.81 ± 0.61 1.09 ± 0.07 0.79 ± 0.16 0.02 ± 0.01 0.90 ± 0.22
 Lung 1.21 ± 0.15 1.02 ± 0.7 0.86 ± 0.17 0.04 ± 0.03 0.85 ± 0.04
 Spleen 0.53 ± 0.14 0.49 ± 0.04 0.43 ± 0.08 0.06 ± 0.03 0.33 ± 0.12
Kidneys 41.80 ± 2.58 40.77 ± 4.34 41.04 ± 7.04 0.26 ± 0.08 16.53 ± 2.22
 Stomach (empty) 2.18 ± 0.76 1.39 ± 0.13 0.96 ± 0.37 0.12 ± 0.11 2.50 ± 0.6
 Intestines (empty) 23.52 ± 7.37 4.56 ± 2.31 1.92 ± 0.52 14.72 ± 19.32 19.59 ± 5.26
 Feces 164.2 ± 72.5 29.48 ± 19.04 11.36 ± 4.29 105.5 ± 128.7 56.00 ± 27.64
 Liver 5.24 ± 1.57 4.05 ± 0.67 2.30 ± 0.54 0.21 ± 0.09 1.71 ± 0.14
 Gall bladder 309.3 ± 187.6 133.2 ± 67.38 55.13 ± n.d. 775.5 ± 206.5 667.4 ± 530.1
 Muscle 1.91 ± 0.25 1.64 ± 0.46 1.17 ± 0.03 0.08 ± 0.09 n.d.
 Bone 1.47 ± 0.05 1.13 ± 0.21 0.84 ± 0.16 0.06 ± 0.06 0.13 ± 0.01
 Salivary glands 8.01 ± 1.16 9.28 ± 1.68 7.03 ± 1.98 0.20 ± 0.18 n.d.
Tumor 3.39 ± 0.54 3.39 ± 0.44 3.54 ± 0.68 0.19 ± 0.07 3.13 ± 0.83
 Ratio of tumor to organ or tissue      
 Blood 16.81 ± 3.13 18.95 ± 2.68 22.72 ± 6.73   24,08 ± 0.82
 Liver 0.69 ± 0.22 0.86 ± 0.19 1.55 ± 0.15   1.18 ± 0.69
Kidney 0.08 ± 0.02 0.08 ± 0.01 0.09 ± 0.01   0.19 ± 1.38
  1. aIn the blockade group, each animal received 100 μg/100 μL of folic acid in PBS 5 min before radiotracer injection; bbiodistribution data of the 18 F-click folate were taken from [15]. n.d., no data. Italicized entries reflect folate receptor-positive tissues/organs.