Scheme 1From: 18 F-click labeling and preclinical evaluation of a new 18 F-folate for PET imaging Synthesis of the azido-folate (5) and the reference compound (6). (a) COMU, TMP, MeCN, rt. (b) DCM/TFA (1:1), rt. (c) COMU, TMP, DMF, rt. (d) 1 M NaOH (aq.), rt. (e) NaH, DMF, 0°C to rt. (f) DCM, DAST, 0°C to rt. (g) Cu(I)I, sodium ascorbate, MeCN, 0.05 M phosphate buffer, DIPEA/2,6-lutidine (1:1), microwave.Back to article page