Figure 1

Functions to generate IFs from blood radioactivity and data of a representative experiment. (A) Exponential functions and scaling factor to calculate plasma form blood radioactivity. If not stated otherwise, the exponential function described in Equation 3 (Wu et al. [14], solid green line) was used in this study. For comparison, IFs were calculated with the bi-exponential function described for rats (Weber et al. [8]; dashed magenta line) and with a constant scaling factor corresponding to the equilibrium partition coefficient of plasma to blood (Wu et al. [14]; dashed orange line). Finally, whole blood was used as IF for comparison (constant factor 1; dashed-dotted brown line). (B) Representative data of an experiment (scan number V1131). Blood time-activity curve (grey), IF as calculated with the function in green in (A) (Wu et al. [14]; Equation 3), TAC of the cortex (red circles), and the hypothalamus (blue squares). Arrow indicates infusion duration.